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SynKinase
JNJ-7706621
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| Product Details | |
|---|---|
| Synonyms | JNJ7706621 |
| Product Type | Chemical |
| Properties | |
| Formula | C15H12F2N6O3S |
| MW | 394.4 |
| CAS | 443797-96-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Aurora A - CDK7 - CDK5 - CDK4 - CDK2 | Kinase Group: Other | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | KDKUVYLMPJIGKA-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDK) and aurora kinases. It demonstrates highest potency on CDK1/2 with IC(50) values of 9nM and 4nM respectively. It shows more than 6-fold selectivity for CDK1/2 over CDK3/4/6.
Product References
- The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases: S. Emanuel, et al.; Cancer Res. 65, 9038 (2005)
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