Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
SynKinase
Purvalanol B
71
CHF
CHF 71.00
In stock
SYN-1070-M0011 mgCHF 71.00
SYN-1070-M0055 mgCHF 106.00
SYN-1070-M01010 mgCHF 142.00
SYN-1070-M05050 mgCHF 546.00
SYN-1070-M100100 mgCHF 937.00
| Product Details | |
|---|---|
| Synonyms | NG95 |
| Product Type | Chemical |
| Properties | |
| Formula | C20H25ClN6O3 |
| MW | 432.9 |
| CAS | 212844-54-7 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: CDK2 - CDK7 - CDK5 - CDK4 | Kinase Group: CMGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | ZKDXRFMOHZVXSG-HNNXBMFYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Purvalanol B is a cyclin-dependent kinase inhibitor with IC(50) values of 6, 6, 9, > 10,000, and 6nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35, respectively. Purvalanol B has also been shown to have anti-proliferative properties, mediated by p42/p44 MAPK.
Product References
- Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors: N.S. Gray, et al.; Science 281, 533 (1998)
- ATP-site directed inhibitors of cyclin-dependent kinases: N. Gray, et al.; Curr. Med. Chem. 6, 859 (1999)
- p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol: M. Knockaert, et al.; Oncogene 21, 6413 (2002)
Related Products
