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SynKinase
SB590885
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | SB-590885 |
| Product Type | Chemical |
| Properties | |
| Formula | C27H27N5O2 |
| MW | 453.5 |
| CAS | 405554-55-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: ARaf - Raf - CRaf - BRaf | Kinase Group: TKL | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | MLSAQOINCGAULQ-QFMPWRQOSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity.
Product References
- Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885: A.J. King, et al.; Cancer Res. 66, 11100 (2006)
- The combination of RAF265, SB590885, ZSTK474 on thyroid cancer cell lines deeply impact on proliferation and MAPK and PI3K/Akt signaling pathways: S. Barollo, et al.; Invest. New Drugs 32, 626 (2014)
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