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Product Details
Synonyms SB-590885
Product Type Chemical
Formula C27H27N5O2
MW 453.5
CAS 405554-55-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: ARaf - Raf - CRaf - BRaf | Kinase Group: TKL | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity.
Product References
  1. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885: A.J. King, et al.; Cancer Res. 66, 11100 (2006)
  2. The combination of RAF265, SB590885, ZSTK474 on thyroid cancer cell lines deeply impact on proliferation and MAPK and PI3K/Akt signaling pathways: S. Barollo, et al.; Invest. New Drugs 32, 626 (2014)
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