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SynKinase
BMS-387032 hydrochloride
CHF 0.00
In stock
SYN-1080-M0011 mgCHF 92.00
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SYN-1080-M01010 mgCHF 248.00
SYN-1080-M05050 mgCHF 858.00
SYN-1080-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | BMS387032; SNS-032 |
| Product Type | Chemical |
| Properties | |
| Formula | C17H24N4O2S2 . HCl |
| MW | 380.5 . 36.5 |
| CAS | 345627-90-9 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: CDK2 - CDK7 - CDK5 - CDK4 | Kinase Group: CMGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | PKCYFIUOIGVHLX-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
BMS387032 is a novel cyclin-dependent kinase inhibitor, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. It inhibits CDK2 with an IC(50) of 48nM and up to 20-fold selective over CDK1/CDK4. It also inhibits CDK7/9 with IC(50) values of 62nM and 4nM. It has little effect on CDK6.
Product References
- N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent: R.N. Misra, et al.; J. Med. Chem. 47, 1719 (2004)
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