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SYN-1087-M0011 mgCHF 99.00
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Product Details
Synonyms TAK715
Product Type Chemical
Formula C24H21N3OS
MW 399.5
CAS 303162-79-0
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: p38 | Kinase Group: CMGC | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
TAK-715 is a potent specific inhibitor of the p38α MAP kinase with an IC(50) of 7.1nM. It is approximately 30-fold more selective for p38α over p38β. It shows no inhibition of p38γ/δ.
Product References
  1. Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent: S. Miwatashi, et al.; J. Med. Chem. 48, 5966 (2005)
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