TAK-715

Specifications / Handling

More Information
Product Details
Synonyms	TAK715
Product Type	Chemical
Properties
Formula	C₂₄H₂₁N₃OS
MW	399.5
CAS	303162-79-0
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO or ethanol.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: p38 \| Kinase Group: CMGC \| Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	HEKAIDKUDLCBRU-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

TAK-715 is a potent specific inhibitor of the p38α MAP kinase with an IC(50) of 7.1nM. It is approximately 30-fold more selective for p38α over p38β. It shows no inhibition of p38γ/δ.

Product References

Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent: S. Miwatashi, et al.; J. Med. Chem. 48, 5966 (2005)

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