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SynKinase
SGX-523
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | SGX523 |
| Product Type | Chemical |
| Properties | |
| Formula | C18H13N7S |
| MW | 359.4 |
| CAS | 1072116-01-8 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: c-Met | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | BCZUAADEACICHN-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
SGX523 is an ATP-competitive, triazolopyridazine-based inhibitor of MET at an IC(50) of 4nM. SGX523 has higher affinity for the unphosphorylated form of MET (Ki = 2.7nM) than the more active phospho-enzyme (Ki = 23nM). In a broad panel of 213 kinases, SGX523 was extremely selective, with no inhibition >36%, suggesting IC(50) values > 1µM, including the closely-associated RON kinase.
Product References
- SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo: S.G. Buchanan, et al.; Mol. Cancer Ther. 8, 3181 (2009)
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