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SynKinase
PP242
71
CHF
CHF 71.00
In stock
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| Product Details | |
|---|---|
| Synonyms | PP-242 |
| Product Type | Chemical |
| Properties | |
| Formula | C16H16N6O |
| MW | 308.3 |
| CAS | 1092351-67-1 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: MEK - MEK5 - MEK2 - MEK1 | Kinase Group: STE | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | MFAQYJIYDMLAIM-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
PP242 exhibits potent selectivity for mTOR over other PI3K family kinases such as p110 α - δ and DNA-PK, with IC(50) of 1.96µM, 2.2µM, 1.27µM, 0.102µM, and 0.408µM, respectively.
Product References
- Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases: B. Apsel, et al.; Nat. Chem. Biol. 4, 691 (2008)
- Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment: Z. Zeng, et al.; Blood 120, 2679 (2012)
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