PP242

CHF 60.00
In stock
SYN-1181-M0011 mgCHF 60.00
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More Information
Product Details
Synonyms PP-242
Product Type Chemical
Properties
Formula C16H16N6O
MW 308.3
CAS 1092351-67-1
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: MEK - MEK5 - MEK2 - MEK1 | Kinase Group: STE | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key MFAQYJIYDMLAIM-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
PP242 exhibits potent selectivity for mTOR over other PI3K family kinases such as p110 α - δ and DNA-PK, with IC(50) of 1.96µM, 2.2µM, 1.27µM, 0.102µM, and 0.408µM, respectively.
Product References
  1. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases: B. Apsel, et al.; Nat. Chem. Biol. 4, 691 (2008)
  2. Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment: Z. Zeng, et al.; Blood 120, 2679 (2012)
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