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SynKinase
PP242
71
CHF
CHF 71.00
In stock
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Product Details | |
---|---|
Synonyms | PP-242 |
Product Type | Chemical |
Properties | |
Formula | C16H16N6O |
MW | 308.3 |
CAS | 1092351-67-1 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Soluble in DMSO or ethanol. |
Declaration | Manufactured by SynKinase. |
Other Product Data |
Target: MEK - MEK5 - MEK2 - MEK1 | Kinase Group: STE | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | MFAQYJIYDMLAIM-UHFFFAOYSA-N |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
Description
PP242 exhibits potent selectivity for mTOR over other PI3K family kinases such as p110 α - δ and DNA-PK, with IC(50) of 1.96µM, 2.2µM, 1.27µM, 0.102µM, and 0.408µM, respectively.
Product References
- Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases: B. Apsel, et al.; Nat. Chem. Biol. 4, 691 (2008)
- Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment: Z. Zeng, et al.; Blood 120, 2679 (2012)