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SynKinase
KW-2449 hydrochloride
71
CHF
CHF 71.00
In stock
SYN-1205-M0011 mgCHF 71.00
SYN-1205-M0055 mgCHF 99.00
SYN-1205-M01010 mgCHF 128.00
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| Product Details | |
|---|---|
| Synonyms | KW2449 |
| Product Type | Chemical |
| Properties | |
| Formula | C20H20N4O . HCl |
| MW | 332.4 . 36.5 |
| CAS | 841259-17-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Aurora A - Abl - FGFR - BCR - fms | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | RTGZMIHOFOOYEY-HCUGZAAXSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC(50) of 6.6nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR.
Product References
- KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation: Y. Shiotsu, et al.; Blood 114, 1607 (2009)
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