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SynKinase
KW-2449 hydrochloride
71
CHF
CHF 71.00
In stock
SYN-1205-M0011 mgCHF 71.00
SYN-1205-M0055 mgCHF 99.00
SYN-1205-M01010 mgCHF 128.00
SYN-1205-M05050 mgCHF 383.00
SYN-1205-M100100 mgCHF 553.00
Product Details | |
---|---|
Synonyms | KW2449 |
Product Type | Chemical |
Properties | |
Formula | C20H20N4O . HCl |
MW | 332.4 . 36.5 |
CAS | 841259-17-4 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Soluble in DMSO or ethanol. |
Declaration | Manufactured by SynKinase. |
Other Product Data |
Target: Aurora A - Abl - FGFR - BCR - fms | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | RTGZMIHOFOOYEY-HCUGZAAXSA-N |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
Description
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC(50) of 6.6nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR.
Product References
- KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation: Y. Shiotsu, et al.; Blood 114, 1607 (2009)