SynKinase

KW-2449 hydrochloride

Name: KW-2449 hydrochloride
Brand: SynKinase
SKU: SYN-1205
Price: 71.00 CHF
Availability: InStock

As low as CHF 71.00

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Specifications / Handling

More Information
Product Details
Synonyms	KW2449
Product Type	Chemical
Properties
Formula	C₂₀H₂₀N₄O . HCl
MW	332.4 . 36.5
CAS	841259-17-4
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO or ethanol.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: Aurora A - Abl - FGFR - BCR - fms \| Kinase Group: RTK \| Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	RTGZMIHOFOOYEY-HCUGZAAXSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC(50) of 6.6nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR.

Product-specific References

KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation: Y. Shiotsu, et al.; Blood 114, 1607 (2009)

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