KW-2449 hydrochloride

CHF 60.00
In stock
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More Information
Product Details
Synonyms KW2449
Product Type Chemical
Properties
Formula C20H20N4O . HCl
MW 332.4 . 36.5
CAS 841259-17-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: Aurora A - Abl - FGFR - BCR - fms | Kinase Group: RTK | Substrate: Tyrosine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key RTGZMIHOFOOYEY-HCUGZAAXSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC(50) of 6.6nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR.
Product References
  1. KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation: Y. Shiotsu, et al.; Blood 114, 1607 (2009)
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