Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
SynKinase
AZD1208
85
CHF
CHF 85.00
In stock
SYN-1214-M0011 mgCHF 85.00
SYN-1214-M0055 mgCHF 114.00
SYN-1214-M01010 mgCHF 142.00
SYN-1214-M05050 mgCHF 497.00
SYN-1214-M100100 mgCHF 922.00
| Product Details | |
|---|---|
| Synonyms | AZD-1208 |
| Product Type | Chemical |
| Properties | |
| Formula | C21H21N3O2S |
| MW | 379.5 |
| CAS | 1204144-28-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Pim-1 / Pim-2 / Pim-3 | Kinase Group: CAMK | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | MCUJKPPARUPFJM-UWCCDQBKSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at < 5nM or < 150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutants. Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2 and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways.
Product References
- Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases: L.A. Dakin, et al.; Bioorg. Med. Chem. Lett. 22, 4599 (2012)
- AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia: E.K. Keeton, et al.; Blood 123, 905 (2014)
- The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling: B. Cen, et al.; Mol. Cell Biol. 34, 2517 (2014)
Related Products
