AZD1208

CHF 72.00
In stock
SYN-1214-M0011 mgCHF 72.00
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SYN-1214-M100100 mgCHF 778.00
 
More Information
Product Details
Synonyms AZD-1208
Product Type Chemical
Properties
Formula C21H21N3O2S
MW 379.5
CAS 1204144-28-4
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: Pim-1 / Pim-2 / Pim-3 | Kinase Group: CAMK | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key MCUJKPPARUPFJM-UWCCDQBKSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at <5nM or <150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutants. Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2 and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways.
Product References
  1. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases: L.A. Dakin, et al.; Bioorg. Med. Chem. Lett. 22, 4599 (2012)
  2. AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia: E.K. Keeton, et al.; Blood 123, 905 (2014)
  3. The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling: B. Cen, et al.; Mol. Cell Biol. 34, 2517 (2014)
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