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SynKinase
AZD1208
As low as
85
CHF
CHF 85.00
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SYN-1214-M0011 mgCHF 85.00
SYN-1214-M0055 mgCHF 114.00
SYN-1214-M01010 mgCHF 142.00
SYN-1214-M05050 mgCHF 497.00
SYN-1214-M100100 mgCHF 922.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | AZD-1208 |
| Product Type | Chemical |
| Properties | |
| Formula | C21H21N3O2S |
| MW | 379.5 |
| CAS | 1204144-28-4 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Pim-1 / Pim-2 / Pim-3 | Kinase Group: CAMK | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | MCUJKPPARUPFJM-UWCCDQBKSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Scientific Background Information
Product Description
Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at < 5nM or < 150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutants. Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2 and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways.
Product-specific References
- Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases: L.A. Dakin, et al.; Bioorg. Med. Chem. Lett. 22, 4599 (2012)
- AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia: E.K. Keeton, et al.; Blood 123, 905 (2014)
- The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling: B. Cen, et al.; Mol. Cell Biol. 34, 2517 (2014)
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