|Solubility||Slightly soluble (<1mg/ml) in DMSO or ethanol.|
|Declaration||Manufactured by SynKinase.|
|Other Product Data||
Target: N/A | Kinase Group: | Substrate: N/A
Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
- Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics: M. Haddach, et al.; ACS Med. Chem. Lett. 3, 602 (2012)