CHF 128.00
In stock
SYN-3031-M0011 mgCHF 128.00
SYN-3031-M0055 mgCHF 227.00
SYN-3031-M01010 mgCHF 355.00
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Product Details
Synonyms CX5461
Product Type Chemical
Formula C27H27N7O2S
MW 513.6
CAS 1138549-36-6
Purity Chemicals ≥95%
Appearance Solid.
Solubility Slightly soluble (<1mg/ml) in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: N/A | Kinase Group: | Substrate: N/A

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

Product References
  1. Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics: M. Haddach, et al.; ACS Med. Chem. Lett. 3, 602 (2012)
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