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SynKinase
CX-5461
128
CHF
CHF 128.00
In stock
SYN-3031-M0011 mgCHF 128.00
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SYN-3031-M01010 mgCHF 355.00
| Product Details | |
|---|---|
| Synonyms | CX5461 |
| Product Type | Chemical |
| Properties | |
| Formula | C27H27N7O2S |
| MW | 513.6 |
| CAS | 1138549-36-6 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Slightly soluble (<1mg/ml) in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: N/A | Kinase Group: | Substrate: N/A Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | XGPBJCHFROADCK-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Product References
- Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics: M. Haddach, et al.; ACS Med. Chem. Lett. 3, 602 (2012)
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