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SynKinase
MPI_5a
114
CHF
CHF 114.00
In stock
SYN-3040-M0011 mgCHF 114.00
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SYN-3040-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | MPI5a; N-Hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide |
| Product Type | Chemical |
| Properties | |
| Formula | C16H17N3O3 |
| MW | 299.3 |
| CAS | 1259296-46-2 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: HDAC6 | Kinase Group: N/A | Substrate: N/A Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | NNQAQGDSGCGFER-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
MPI_5a is a potent selective inhibitor of HDAC6. HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin and heat shock protein 90, and other substrates. MPI-5a has an IC50 of 36nM in tumour cell models and inhibits the acetylation of tubulin in cells with an IC50 value of 210nM.
Product References
- HDAC6: physiological function and its selective inhibitors for cancer treatment: P.H. Yang, et al.; Drug Discov. Ther. 7, 233 (2013)
- Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform: C. Blackburn, et al.; J. Med. Chem. 56, 7201 (2013)