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AdipoGen Life Sciences
anti-Adiponectin (human), mAb (HADI 773)
Product Details | |
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Synonyms | ACRP30; AdipoQ; apM1; GBP28; Adipocyte Complement Related Protein of 30kDa |
Product Type | Monoclonal Antibody |
Properties | |
Clone | HADI 773 |
Isotype | Mouse IgG1κ |
Immunogen/Antigen | Recombinant human adiponectin. |
Application |
ELISA: (direct and indirect: 1:5'000-1:10'000). |
Crossreactivity | Human |
Specificity |
Recognizes human adiponectin. Detects a band of ~30kDa by Western blot. Cross-reactivity with other species not tested. |
Purity Detail | Protein G-affinity purified. |
Concentration | 1mg/ml |
Formulation | Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
Isotype Negative Control | |
RRID | AB_2490083 |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels.
- Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus: B.S. Youn, et al.; J. Clin. Endocrinol. Metab. 89, 150 (2004)
- Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population: Y.Y. Lee, et al.; Diabet. Med. 22, 569 (2005)
- Adiponectin expression in human fetal tissues during mid- and late gestation: S. Corbetta, et al,; J. Clin. Endocrinol. Metab. 90, 2397(2005)
- Renin receptor expression in human adipose tissue: V. Achard, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R274 (2007)
- Adiponectin immunohistochemical expression in colorectal cancer and its correlation with histological grade and tumour microvessel density: V. Barresi, et al.; Pathology 41, 533 (2009)
- The expression of adiponectin receptors Adipo-R1 and Adipo-R2 is associated with an intestinal histotype and longer survival in gastric carcinoma: V. Barresi, et al.; J. Clin. Pathol. 62, 705 (2009)
- Effect of monomeric adiponectin on cardiac function and perfusion in anesthetized pig: E. Grossini, et al.; J. Endocrinol. 222, 137 (2014)
- Acute vitamin D3 supplementation in severe obesity: Evaluation of multimeric adiponectin: S. Mai, et al.; Nutrients 9, 459 (2017)