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AdipoGen Life Sciences
anti-Sirtuin 2 (human), mAb (S2R233-1)
270
CHF
CHF 270.00
In stock
AG-20A-0076-C05050 µgCHF 270.00
AG-20A-0076-C100100 µgCHF 350.00
Figure 1: Western blot analysis using anti-Sirtuin 2 (human), mAb (S2R233-1) (Prod. No. AG-20A-0076) at 1:4'000 dilution.
1: Human sirtuin 2 (His-tagged).
2: Human sirtuin 1 (His-tagged).
3: Human sirtuin 5 (His-tagged).
4: Human sirtuin 6 (His-tagged).
5: HEK 293 cell lysate.
6: Human globular Adiponectin (His-tagged) (negative control).
1: Human sirtuin 2 (His-tagged).
2: Human sirtuin 1 (His-tagged).
3: Human sirtuin 5 (His-tagged).
4: Human sirtuin 6 (His-tagged).
5: HEK 293 cell lysate.
6: Human globular Adiponectin (His-tagged) (negative control).
| Product Details | |
|---|---|
| Synonyms | SIRT2; NAD-dependent Deacetylase Sirtuin-2; SIR2-like protein 2; SIR2L2 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | S2R233-1 |
| Isotype | Mouse IgG2bκ |
| Immunogen/Antigen | Recombinant human sirtuin 2. |
| Application |
ELISA: (direct and indirect: 1:2’000-1:5’000) |
| Crossreactivity | Human |
| Specificity |
Recognizes human sirtuin 2. Detects a band of ~45kDa by Western blot. |
| Purity Detail | Protein G-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer’s disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington’s and Parkinson’s disease.
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