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AdipoGen Life Sciences
anti-CTRP6 (human), mAb (256-E)
190
CHF
CHF 190.00
In stock
AG-20A-0093-C05050 µgCHF 190.00
AG-20A-0093-C100100 µgCHF 320.00
Figure 1: Immunohistochemical staining of CTRP6 using anti-CTRP6 (human), mAb (256-E) (Prod. No. AG-20A-0093) in human tissue.
Method: A. Paraffin-embedded human kidney tissue, showing stained cell cytoplasm using anti-CTRP6 (human), mAb (256-E) at dilution 1:200 (under X100 lens, Brown color). B. Human kidney stained with isotype control IgG1κ (Negative control, under X100 lens).
Method: A. Paraffin-embedded human kidney tissue, showing stained cell cytoplasm using anti-CTRP6 (human), mAb (256-E) at dilution 1:200 (under X100 lens, Brown color). B. Human kidney stained with isotype control IgG1κ (Negative control, under X100 lens).
Figure 2: Western blot analysis of recombinant human CTRP6 using anti-CTRP6 (human), mAb (256-E) (Prod. No. AG-20A-0093) at 1:500 dilution:
1. Recombinant human CTRP6 (globular domain-less) protein (His-tagged).
2. Recombinant human CTRP6 (full-length) Protein (FLAG).
3. hCTRP6-FLAG (full-length) transfected HEK293 cell lysates.
4. Empty vector transfected HEK293 cell lysates.
5. Recombinant human CTRP6 (globular domain) protein (His-tagged).
6. An unrelated protein (His-tagged).
1. Recombinant human CTRP6 (globular domain-less) protein (His-tagged).
2. Recombinant human CTRP6 (full-length) Protein (FLAG).
3. hCTRP6-FLAG (full-length) transfected HEK293 cell lysates.
4. Empty vector transfected HEK293 cell lysates.
5. Recombinant human CTRP6 (globular domain) protein (His-tagged).
6. An unrelated protein (His-tagged).
| Product Details | |
|---|---|
| Synonyms | Complement C1q Tumor Necrosis Factor-related Protein 6; C1QTNF6; C1qTNF-related Protein 6; ZACRP 6 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | 256-E |
| Isotype | Mouse IgG1κ |
| Immunogen/Antigen | Recombinant human CTRP6 (globular domain-less). |
| Application |
ELISA: (direct or indirect: 1:200-1:500) Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS. |
| Crossreactivity | Human |
| Specificity |
Recognizes the N-terminal half of human CTRP6 full-length protein. Detects bands of ~16kDa and ~32kDa by Western blot. |
| Purity Detail | Protein G-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
CTRP6 mediates the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in skeletal muscle cells, subsequently mediating glycogen accumulation and fatty acid oxidation. It induces the expression of the potent anti-inflammatory cytokine IL-10 in macrophages. CTRP6 may be a potential serum marker for hepatocellular carcinoma, contributing to tumor angiogenesis by activating the Akt pathway. CTRP6 was also shown to be associated with obesity, type 1 diabetes mellitus (T1D), vitiligo (depigmentation of the skin) and ASFV (African Swine Fever Virus). CTRP6 forms homotrimers and higher-order oligomers and it may also form heteromeric complexes with CTRP1. May be involved in kidney inflammation.
Product References
- C1q/TNF-Related Protein 6 Is a Pattern Recognition Molecule That Recruits Collectin-11 from the Complement System to Ligands: N. Kirketerp-Møller, et al.; J. Immunol. 204, 1598 (2020)
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