AdipoGen Life Sciences

anti-CTRP6 (human), mAb (256-E)

CHF 190.00
In stock
AG-20A-0093-C05050 µgCHF 190.00
AG-20A-0093-C100100 µgCHF 320.00
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Product Details
Synonyms Complement C1q Tumor Necrosis Factor-related Protein 6; C1QTNF6; C1qTNF-related Protein 6; ZACRP 6
Product Type Monoclonal Antibody
Properties
Clone 256-E
Isotype Mouse IgG1κ
Immunogen/Antigen Recombinant human CTRP6 (globular domain-less).
Application

ELISA: (direct or indirect: 1:200-1:500)
Immunohistochemistry (paraffin sections): 1:200
Western blot: (1:200-1:500 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions should be determined individually for each application.

Note: Tested on recombinant proteins and/or target-protein transfected cell lines in ELISA, Western Blot and/or FACS.

Crossreactivity Human
Specificity

Recognizes the N-terminal half of human CTRP6 full-length protein. Detects bands of ~16kDa and ~32kDa by Western blot.

Purity Detail Protein G-affinity purified.
Concentration 1mg/ml
Formulation Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Isotype Negative Control

Mouse IgG1 Isotype Control

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

CTRP6 mediates the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in skeletal muscle cells, subsequently mediating glycogen accumulation and fatty acid oxidation. It induces the expression of the potent anti-inflammatory cytokine IL-10 in macrophages. CTRP6 may be a potential serum marker for hepatocellular carcinoma, contributing to tumor angiogenesis by activating the Akt pathway. CTRP6 was also shown to be associated with obesity, type 1 diabetes mellitus (T1D), vitiligo (depigmentation of the skin) and ASFV (African Swine Fever Virus). CTRP6 forms homotrimers and higher-order oligomers and it may also form heteromeric complexes with CTRP1. May be involved in kidney inflammation.

Product References
  1. C1q/TNF-Related Protein 6 Is a Pattern Recognition Molecule That Recruits Collectin-11 from the Complement System to Ligands: N. Kirketerp-Møller, et al.; J. Immunol. 204, 1598 (2020)
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