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AdipoGen Life Sciences
anti-NLRP6/NALP6 (human), mAb (Clint-1)
480
CHF
CHF 480.00
In stock
AG-20B-0046-C100100 µgCHF 480.00
Figure 1: Immunohistochemical staining of bioptic sections of small intestine using anti-NLRP6/NALP6 (human), mAb (Clint-1) (AG-20B-0046) at 1:500 dilution. Method: A) Epithelial tissues which express NLRP6 (positive control) (black arrows) and connective tissues which do not express NLRP6 (negative control) (red arrows) are stained using Clint-1. B) Control confirming non-reactive specificity of the secondary antibody without Clint-1.
| Product Details | |
|---|---|
| Synonyms | NACHT-, LRR and PYD Domains-containing Protein 6; Nod-like Receptor Pyrin Domain-containing Protein 6; NLRP6; Angiotensin II/Vasopressin Receptor; PYRIN-containing APAF1-like Protein 5; NALP6 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | Clint-1 |
| Isotype | Mouse IgG1κ |
| Source/Host | Purified from concentrated hybridoma tissue culture supernatant. |
| Immunogen/Antigen | Recombinant human NLRP6 (NACHT domain). |
| Application |
Western Blot: (1μg/ml) |
| Crossreactivity | Human |
| Specificity |
Recognizes human NLRP6. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein G-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1β and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.
Product References
- Examining the Role of Non-Canonical NOD-like Receptors and Inflammasomes in Inflammation and Disease: J.M. Platnych, Doctoral Thesis University of Calgary doi:10.11575/PRISM/31757 (2018)
- Tissue-selective alternate promoters guide NLRP6 expression: N.A. Bracey, et al.; Life Sci. Alliance 4, e202000897 (2020)
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