anti-NLRP6/NALP6 (human), mAb (Clint-1)

CHF 480.00
In stock
AG-20B-0046-C100100 µgCHF 480.00
More Information
Product Details
Synonyms NACHT-, LRR and PYD Domains-containing Protein 6; Nod-like Receptor Pyrin Domain-containing Protein 6; NLRP6; Angiotensin II/Vasopressin Receptor; PYRIN-containing APAF1-like Protein 5; NALP6
Product Type Monoclonal Antibody
Properties
Clone Clint-1
Isotype Mouse IgG1κ
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Recombinant human NLRP6 (NACHT domain).
Application

Western Blot: (1μg/ml)
Immunohistochemistry: (frozen sections) (1:500)

Crossreactivity Human
Specificity

Recognizes human NLRP6.

Purity ≥95% (SDS-PAGE)
Purity Detail Protein G-affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Isotype Negative Control

Mouse IgG1 Isotype Control

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1β and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

Product References
  1. Examining the Role of Non-Canonical NOD-like Receptors and Inflammasomes in Inflammation and Disease: J.M. Platnych, Doctoral Thesis University of Calgary doi:10.11575/PRISM/31757 (2018)
  2. Tissue-selective alternate promoters guide NLRP6 expression: N.A. Bracey, et al.; Life Sci. Alliance 4, e202000897 (2020)
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