anti-IL-38, mAb (Nhat-1)

CHF 540.00
In stock
AG-20B-0070-C100100 µgCHF 540.00
 
More Information
Product Details
Synonyms Interleukin-38; Interleukin-1 Family Member 10; IL-1F10
Product Type Monoclonal Antibody
Properties
Clone Nhat-1
Isotype Mouse IgG2bκ.
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Recombinant human IL-38.
Application Western Blot: (1:1'000)
ICC: (1:500)
ELISA: (1:2'000)
Crossreactivity Human
Mouse
Specificity Recognizes human and mouse IL-38.
Purity ≥95% (SDS-PAGE)
Purity Detail Protein A affinity purified.
Concentration 1mg/ml
Formulation Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.
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