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AdipoGen Life Sciences
anti-IL-38, mAb (Nhat-1)
540
CHF
CHF 540.00
In stock
AG-20B-0070-C100100 µgCHF 540.00
Figure 1: Mouse and human IL-38 is detected using anti-IL-38, mAb (Nhat-1) (AG-20B-0070).
Method: Recombinant mouse IL-38 (AG-40B-0101) (lane 1), cell extracts from HEK 293 cells mock-transfected (lane 2) or transfected with human IL-38 (lane 3) were separated by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with anti-IL-38, mAb (Nhat-1) (1µg/ml). Proteins are visualized by a chemiluminescence detection system.
Method: Recombinant mouse IL-38 (AG-40B-0101) (lane 1), cell extracts from HEK 293 cells mock-transfected (lane 2) or transfected with human IL-38 (lane 3) were separated by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with anti-IL-38, mAb (Nhat-1) (1µg/ml). Proteins are visualized by a chemiluminescence detection system.
| Product Details | |
|---|---|
| Synonyms | Interleukin-38; Interleukin-1 Family Member 10; IL-1F10 |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | Nhat-1 |
| Isotype | Mouse IgG2bκ. |
| Source/Host | Purified from concentrated hybridoma tissue culture supernatant. |
| Immunogen/Antigen | Recombinant human IL-38. |
| Application |
Western Blot: (1:1'000) |
| Crossreactivity |
Human Mouse |
| Specificity |
Recognizes human and mouse IL-38. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein A affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.
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