AdipoGen Life Sciences

anti-Podoplanin (mouse), mAb (RTD4E10)

Name: anti-Podoplanin (mouse), mAb (RTD4E10)
Brand: AdipoGen Life Sciences
SKU: AG-20T-0101
Price: 490.00 CHF
Availability: InStock

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AG-20T-0101-C100100 µgCHF 490.00

Specifications / Handling

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Product Details
Synonyms	Glycoprotein 36; PA2.26 Antigen; Aggrus
Product Type	Monoclonal Antibody
Properties
Clone	RTD4E10
Isotype	Hamster IgG
Immunogen/Antigen	Murine thymic stromal cell line.
Application	Immunohistochemistry: (1-10μg/ml) Immunoprecipitation: (2-10μg/ml) Western Blot: (1-5μg/ml) ELISA: (functional ELISA) Optimal conditions must be determined individually for each application.
Crossreactivity	Mouse
Specificity	Recognizes mouse podoplanin. Does not cross-react with human podoplanin.
Purity	Protein G purified.
Purity Detail	Protein G-affinity purified.
Formulation	Lyophilized.
Reconstitution	Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0mg/ml.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Product-specific References

Mouse lungs contains endothelial progenitors with high capacity to form blood and lymphatic vessels: J. Schniedermann, et al.; BMC Cell Biology 11, 1471 (2010)

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