anti-VEGF-A (human), mAb (3(6D3))

CHF 415.00
In stock
AG-20T-0105-C200200 µgCHF 415.00
More Information
Product Details
Synonyms Vascular Endothelial Growth Factor-A; VPF
Product Type Monoclonal Antibody
Properties
Clone 3(6D3)
Isotype Mouse IgG1
Immunogen/Antigen Recombinant human VEGF 165.
Application

ELISA: (1-15μg/ml)
Functional Application: Neutralization. Inhibits VEGF-A signaling.
Western Blot: (2-10μg/ml)
Optimal conditions must be determined individually for each application.

Crossreactivity Human
Purity Protein G purified.
Purity Detail Protein G purified.
Formulation Lyophilized from a buffer containing Trehalose, Na-Phosphate and Polysorbat 20.
Reconstitution Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0mg/ml.
Isotype Negative Control

Mouse IgG1 Isotype Control

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Human vascular endothelial growth factor (VEGF 165) is produced as a homodimer. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. VEGF-A is a specific mitogen for vascular endothelial cells and a strong angiogenic factor in vivo. In addition to its action as a mitogen it is a potent vascular permeability factor (VPF) in vivo. It is also a chemoattractant molecule for monocytes and endothelial cells. It induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.

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