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AdipoGen Life Sciences
anti-FOXP3 (mouse), pAb
390
CHF
CHF 390.00
In stock
AG-25A-0020-C100100 µgCHF 390.00
Figure 1: Western blot analysis using anti-FOXP3 (mouse), pAb (Prod. No. AG-25A-0020) at 1:3'000 dilution.
1: Mouse FOXP3 (His-tagged).
2: Transfected mouse FOXP3 cell lysate (HEK 293).
3: Mouse T lymphocyte (CD4+) cell lysate.
4: PHA treated mouse T cell (CD4+) cell lysate.
1: Mouse FOXP3 (His-tagged).
2: Transfected mouse FOXP3 cell lysate (HEK 293).
3: Mouse T lymphocyte (CD4+) cell lysate.
4: PHA treated mouse T cell (CD4+) cell lysate.
| Product Details | |
|---|---|
| Synonyms | Forkhead Box Protein P3; Scurfin |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rat |
| Immunogen/Antigen | Recombinant mouse FOXP3. |
| Application |
ELISA: (direct and indirect: 1:2’000-1:10’000) Western Blot: (1:2’000-1:5'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application. |
| Crossreactivity | Mouse |
| Specificity | Recognizes mouse FOXP3. Detects a band of ~46-49kDa by Western blot. |
| Purity Detail | Protein A-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX); also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.
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