AdipoGen Life Sciences

anti-RBP4 (mouse), pAb

CHF 390.00
In stock
AG-25A-0036-C100100 µgCHF 390.00
More Information
Product Details
Synonyms Retinol Binding Protein 4
Product Type Polyclonal Antibody
Properties
Source/Host Rabbit
Immunogen/Antigen Recombinant mouse RBP4.
Application

ELISA: (direct and indirect: 1:2’000-1:5’000)
Western Blot: (1:2’000-1:5’000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.

Crossreactivity Mouse
Specificity

Recognizes mouse RBP4. Detects a band of ~22-25kDa by Western blot.

Purity Detail Protein A-affinity purified.
Concentration 1mg/ml
Formulation Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Isotype Negative Control

Rabbit IgG

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Retinol binding protein 4 (RBP4; RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function.

Product References
  1. The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis: E. Chiefari, et al.; BMC Biol. 7, 24 (2009)
  2. Interleukin-6 mediates exercise-induced increase in insulin sensitivity in mice: A. Benrick, et al.; Exp. Physiol. 97, 1224 (2012)
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