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AdipoGen Life Sciences
anti-SLP-2, pAb
440
CHF
CHF 440.00
In stock
AG-25B-0019-C100100 µgCHF 440.00
Figure 1: Endogenous SLP-2 is localized to the mitochondria (Immunocytochemical staining).
Endogenous SLP-2 (green) (up) and endogenous mitochondrial HSP70 (red) (middle) were detected in methanol fixed HeLa cells using anti-SLP-2, pAb (Prod. No. AG-20B-0019) (1:100) and a pAb to mitochondrial HSP70, respectively.
Picture courtesy of Dr. Sandrine Da Cruz, University of Geneva.
Endogenous SLP-2 (green) (up) and endogenous mitochondrial HSP70 (red) (middle) were detected in methanol fixed HeLa cells using anti-SLP-2, pAb (Prod. No. AG-20B-0019) (1:100) and a pAb to mitochondrial HSP70, respectively.
Picture courtesy of Dr. Sandrine Da Cruz, University of Geneva.
| Product Details | |
|---|---|
| Synonyms | Stomatin-like Protein 2; EPB72-like 2 |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Synthetic peptide corresponding to aa 199-213 of mouse SLP-2. |
| Application |
Immunocytochemistry: (1:100) |
| Crossreactivity |
Human Mouse Rat |
| Specificity |
Recognizes human, mouse and rat SLP-2. |
| Purity Detail | Protein A-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS containing 0.02% sodium azide. |
| Isotype Negative Control | |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
SLP-2 (stomatin-like protein 2) is an unusual stomatin homolog. It is a mitochondrial protein and functions in energy process by MMP maintenance and subsequently affecting cell motility, proliferation and chemosensitivity. SLP-2 was identified as a cancer-related gene overexpressed in human ESCC, lung cancer, laryngeal cancer and endometrial adenocarcinoma. In tumor cells, SLP-2 promotes cell growth, cell adhesion and tumorigenesis.
Product References
- SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability: S. Da Cruz, et al.; Biochim. Biophys. Acta 1783, 904 (2008)
- SLP-2 is required for stress-induced mitochondrial hyperfusion: D. Tondera, et al.; EMBO J. 28, 1589 (2009)
- Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2: A. Zanon, et al.; J. Transl. Med. 22, 59 (2024)