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AdipoGen Life Sciences
anti-Pyrin (human), pAb (AL196)
420
CHF
CHF 420.00
In stock
AG-25B-0020-C100100 µgCHF 420.00
| Product Details | |
|---|---|
| Synonyms | Marenostrin; MEFV; TRIM20 |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Synthetic peptide corresponding to aa 2-29 (A2KTPSDHLLSTLEELVPYDFEKFKFKLQ29) of human pyrin. |
| Application |
Immunoprecipitation: (1:100) |
| Crossreactivity | Human |
| Specificity |
Recognizes human pyrin. |
| Purity | Epitope-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Isotype Negative Control | |
| Accession Number | O15553 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Pyrin regulates inflammation by interacting with the cytoskeleton. Pyrin may direct the migration of white blood cells to sites of inflammation and stop or slow the inflammatory response when it is no longer needed. Defects in pyrin are the cause for Mediterranean fever.
Product References
- The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing: S. Papin, et al.; Cell Death Differ. 14, 1457 (2007)
- Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation: S.L. Masters, et al., Sci. Transl. Med. 8, 332ra45 (2016)
- A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of Pyrin and distinction to Familial Mediterranean Fever: F. Moghaddas, et al.; Ann. Rheum.Dis. 76, 2085 (2017)
- Lack of Protein Prenylation Promotes Nlrp3 Inflammasome Assembly in Human Monocytes: O.P. Skinner, et al.; J. Allergy Clin. Immunol. 143, 2315 (2019) [KO validation]
- Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients: F. Magnotti, et al.; EMBO Mol. Med. 11, e10547 (2019)
- Statins repress needle-like carbon nanotube- or cholesterol crystal-stimulated IL-1β production by inhibiting the uptake of crystals by macrophages: H. Cui, et al.; Biochem. Pharmacol. 188, 114580 (2021)
- Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation: D. Chirita, et al.; Cell Death Dis. 14, 213 (2023)
- Gain-of-function of MEFV Mutation Causes Very Early Onset Inflammatory Bowel Disease: Q. Wang, et al.; J. Clin. Immunol. ahead of print (2023)
- A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes: Q. Wang, et al.; JCI Insight 8, e172975 (2023)
- Pyrin variant E148Q potentiates inflammasome activation and the effect of pathogenic mutations in cis: T. Reygaerts, et al.; Rheumatology, ahead of print (2023)
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