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AdipoGen Life Sciences
anti-PROX1, pAb
350
CHF
CHF 350.00
In stock
AG-25T-0105-C05050 µgCHF 350.00
Figure 1: Immunofluorescence staining (green) of cryo-sections of human foreskin (fixed 15 min in 4% PFA) using anti-PROX1, pAb (dilution 1:200) (Prod. No. AG-25T-0105) and counter staining of nuclei with Dapi. A) Specific green PROX1 signal in the nuclei of lymphatics (L). Ep=epidermis.
Figure 2: Immunohistochemical detection of endogenous PROX1 (paraffin sections) in equine mandibular lymph nodeusing anti-PROX1, pAb (dilution 1:200) (Prod. No. AG-25T-0105), counterstained with toluidine blue. Sinusoids (S) as well as lymphatic vessels in the hilum of the lymph node (arrows) are lined by positively stained lymphatic endothelial cells. Blood vascular endothelium remains unstained (arrow heads). LC=Cluster of lymphocytes.
| Product Details | |
|---|---|
| Synonyms | Prox-1; Prospero Homeobox Protein 1 |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant human PROX1 (aa547-737). |
| Application |
Immunohistochemistry: (frozen section 1:750-1000) |
| Crossreactivity |
Avian Horse Human |
| Specificity |
Recognizes human, chicken and horse PROX1. |
| Purity | Antigen affinity purified. |
| Purity Detail | Antigen affinity purified. |
| Formulation | Lyophilized, 5 mM PBS, pH 7.2. |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0mg/ml. |
| Isotype Negative Control | |
| Other Product Data |
UniProt ID Q92786: Prox-1 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Expression of PROX1 in blood endothelial cells induces expression of other lymphatic marker genes. Together with podoplanin, PROX1 can be used to reliably distinguish lympathic vessels from blood vessels. PROX1 is expressed in CNS, eye, pancreas, liver and heart, and it is one of the most specific and reliable markers for lymphatic endothelial cells.
Product References
- The Sialomucin CD34 Is a Marker of Lymphatic Endothelial Cells in Human Tumors: U. Fidler, et al.; Am. J. Pathol. 168, 1045 (2006)
- Lymphatic capillary hypoplasia in the skin of fetuses with increased nuchal translucency and Turner's syndrome: comparison with trisomies and controls: C.S. von Kaisenberg, et al.; Mol. Hum. Reprod. 16, 778 (2010)
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