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AdipoGen Life Sciences
anti-Lipoma Preferred Partner, pAb (IG-817)
Product Details | |
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Synonyms | LPP; LIM Domain-containing Preferred Translocation Partner in Lipoma |
Product Type | Polyclonal Antibody |
Properties | |
Source/Host | Rabbit |
Immunogen/Antigen | Recombinant human lipoma preferred partner (LPP) (aa 1-109). |
Application |
Immunocytochemistry: (1:500) |
Crossreactivity |
Human Pig Rat |
Specificity |
Recognizes human, rat and pig LPP. |
Purity | Antigen affinity purified. |
Purity Detail | Affinity purified on the antigen after proteolytic cleavage and removal of the fusion partner GST. |
Concentration | 500μg/ml |
Formulation | Liquid. In PBS containing 0.01% sodium azide. |
Isotype Negative Control | |
Accession Number | UniProt ID Q93052: LPP (human) |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Do not freeze/thaw. |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Download PDF |
Product Specification Sheet | |
Datasheet | Download PDF |
Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1), LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions). Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity.
- LPP, a LIM protein highly expressed in smooth muscle: I. Gorenne, et al.; Am. J. Physiol. Cell Physiol. 285, 674 (2003)
- Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration: L. Jin, et al.; Circ Res. 100, 817 (2007)
- The Actin-associated Protein Palladin Is Required for Development of Normal Contractile Properties of Smooth Muscle Cells Derived from Embryoid Bodies: L. Jin, et al.; J. Biol. Chem. 284, 2121 (2009)
- Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury: L. Jin, et al.; J. Muscle Res. Cell. Motil. 30, 41 (2009)
- ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas: E. Colas, et al.; Oncogene 31, 4778 (2012)
- Cells lacking β-actin are genetically reprogrammed and maintain conditional migratory capacity: D. Tondeleir, et al.; Mol. Cell Proteom. 11, 255 (2012)
- Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein–protein interactions: S. Mihlan, et al.; Oncogene 32, 2107 (2013)