AdipoGen Life Sciences

anti-Activin Receptor IIB, pAb (IG-510)

CHF 470.00
In stock
AG-25T-0114-C05050 µgCHF 470.00
More Information
Product Details
Synonyms ACVR2B; ACTR-IIB; Activin receptor type-2B
Product Type Polyclonal Antibody
Properties
Source/Host Rabbit
Immunogen/Antigen Recombinant extracellular domain (ecd) of mouse activin receptor IIB.
Application

ELISA: (1:400)
Western Blot: (1:5000)
Optimal conditions must be determined individually for each application.

Crossreactivity Human
Mouse
Specificity

Recognizes the extracellular domain of human and mouse ACTR-IIB. Does not cross-react with related human proteins ActR-IIecd, BMPR-IIecd, BMPR-IAecd, BMPR-IBecd or ActR-Iecd.

Purity Antigen affinity purified.
Concentration 500μg/ml
Formulation Liquid. In PBS with 1 mg/ml BSA and 0.02% sodium azide.
Isotype Negative Control

Rabbit IgG

Accession Number UniProt ID Q13705: ACTR-IIB
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Activin Receptor IIB (ACTR-IIB) is a transmembrane receptor that forms an activin receptor complex with activin type-1 receptors (ACVR1, ACVR1B or ACVR1c). ACTR-IIB transduces the activin signal from the cell surface to the cytoplasm and regulates therefore many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.

Product References
  1. Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB): A. Kotzsch, et al.; Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun 65, 779 (2009)
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