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AdipoGen Life Sciences
anti-Activin Receptor IIB, pAb (IG-510)
470
CHF
CHF 470.00
In stock
AG-25T-0114-C05050 µgCHF 470.00
Figure 1: Western blot with extracellular domains (ecd) of different related human receptors (50ng per lane) reveals that anti-Activin Receptor IIB, pAb (IG-510) (Prod. No. AG-25T-0114) (dilution 1:5000) specifically recoginzes ACTR-IIB under nonreducing (-ßME, left panel) and reducing (+ßME; right panel) conditions, but none of the other receptor types tested.
Figure 2: ELISA detection using anti-Activin Receptor IIB, pAb (IG-510) (Prod. No. AG-25T-0114). Wells were coated with 100μl of ACTR-IIB extracellular domain (ecd) at 2μg/ml. For detection different dilutions of anti-Activin Receptor IIB, pAb (IG-510) stock solution (500μg/ml) were applied, followed by an ALP-conjugated goat-anti-rabbit antibody.
| Product Details | |
|---|---|
| Synonyms | ACVR2B; ACTR-IIB; Activin receptor type-2B |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant extracellular domain (ecd) of mouse activin receptor IIB. |
| Application |
ELISA: (1:400) |
| Crossreactivity |
Human Mouse |
| Specificity |
Recognizes the extracellular domain of human and mouse ACTR-IIB. Does not cross-react with related human proteins ActR-IIecd, BMPR-IIecd, BMPR-IAecd, BMPR-IBecd or ActR-Iecd. |
| Purity | Antigen affinity purified. |
| Concentration | 500μg/ml |
| Formulation | Liquid. In PBS with 1 mg/ml BSA and 0.02% sodium azide. |
| Isotype Negative Control | |
| Accession Number | UniProt ID Q13705: ACTR-IIB |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Activin Receptor IIB (ACTR-IIB) is a transmembrane receptor that forms an activin receptor complex with activin type-1 receptors (ACVR1, ACVR1B or ACVR1c). ACTR-IIB transduces the activin signal from the cell surface to the cytoplasm and regulates therefore many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.
Product References
- Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB): A. Kotzsch, et al.; Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun 65, 779 (2009)
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