anti-IL-1R2 (mouse), mAb (rec.) (Praxy-1-1)

CHF 400.00
In stock
AG-27B-0011-C100100 µgCHF 400.00
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Product Details
Synonyms CD121 Antigen-like Family Member B; IL-1 Type II Receptor; Interleukin-1 Receptor β Interleukin-1 Receptor Type II; CD121b
Product Type Recombinant Antibody
Properties
Clone Praxy-1-1
Isotype Mouse IgG2bλ
Source/Host Produced without the use of animals. Purified from HEK 293 cell culture supernatant.
Immunogen/Antigen Recombinant mouse IL-1R2 (extracellular domain).
Application

ELISA: Detection
Flow Cytometry: (1:100)

Crossreactivity Mouse
Specificity

Recognizes mouse IL-1R2.

Purity ≥95% (SDS-PAGE)
Purity Detail Protein A-affinity purified.
Endotoxin Content <0.01EU/μg purified protein (LAL-test; Lonza).
Concentration 1mg/ml.
Formulation Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Isotype Negative Control

Mouse IgG2b Isotype Control

Other Product Data

IL-1R2 (mouse) monoclonal antibody (recombinant) (Praxy-1-1) is composed of human variable regions (VH and VL) (λ-chain) of immunoglobulin fused to the mouse IgG2b Fc domain.

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 month after receipt when stored at +4°C.
Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

The inflammatory actions of IL-1α and β depend on their interaction with its receptor, IL-1R1, and can be negatively controlled by several inhibitors such as IL-1Ra, IL-1R type 2 (IL-1R2), SIGIRR and the soluble form of IL-1 receptor accessory protein (IL-1RAcP). IL-1R2 neutralizes IL-1 either as a surface decoy receptor or in a cleaved and secreted form. IL-1R2 is expressed on B cells, on neutrophils and on in vitro expanded human Tregs.

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