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AdipoGen Life Sciences
anti-IL-1R2 (mouse), mAb (rec.) (Praxy-1-1)
360
CHF
CHF 360.00
In stock
AG-27B-0011-C100100 µgCHF 360.00
Figure 1: Structure of the recombinant antibody anti-IL-1R2 (mouse), mAb (rec.) (Praxy-1-1) (Prod. No. AG-27B-0011). The single chain variable human fragment (ScFv) selected by antibody phage display technology and specific to the antigen of interest is fused to a mouse IgG2b Fc region.
Figure 2: Detection of endogenous mouse IL-1R2 with IL-1R2 (mouse), mAb (rec.) (Praxy-1-1) (AG-27B-0011). Method: In vitro-cultivated BMN (mouse Neutrophils) (stimulated 24h with hydrocortisone) were stained with IL-1R2 (mouse), mAb (rec.) (Praxy-1-1) (thick green line) or an isotype control (thin black line) at 5μg/ml each, revealed with a secondary anti-mouse antibody (FITC) and then analyzed by flow cytometry.
| Product Details | |
|---|---|
| Synonyms | CD121 Antigen-like Family Member B; IL-1 Type II Receptor; Interleukin-1 Receptor β Interleukin-1 Receptor Type II; CD121b |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | Praxy-1-1 |
| Isotype | Mouse IgG2bλ |
| Source/Host | Produced without the use of animals. Purified from HEK 293 cell culture supernatant. |
| Immunogen/Antigen | Recombinant mouse IL-1R2 (extracellular domain). |
| Application |
ELISA: Detection |
| Crossreactivity | Mouse |
| Specificity |
Recognizes mouse IL-1R2. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein A-affinity purified. |
| Endotoxin Content | <0.01EU/μg purified protein (LAL-test; Lonza). |
| Concentration | 1mg/ml. |
| Formulation | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
IL-1R2 (mouse) monoclonal antibody (recombinant) (Praxy-1-1) is composed of human variable regions (VH and VL) (λ-chain) of immunoglobulin fused to the mouse IgG2b Fc domain. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability |
Stable for at least 1 month after receipt when stored at +4°C. Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
The inflammatory actions of IL-1α and β depend on their interaction with its receptor, IL-1R1, and can be negatively controlled by several inhibitors such as IL-1Ra, IL-1R type 2 (IL-1R2), SIGIRR and the soluble form of IL-1 receptor accessory protein (IL-1RAcP). IL-1R2 neutralizes IL-1 either as a surface decoy receptor or in a cleaved and secreted form. IL-1R2 is expressed on B cells, on neutrophils and on in vitro expanded human Tregs.
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