IL-1 Receptor Type I (human):Fc (human) (recombinant protein)

Specifications / Handling

More Information
Product Details
Synonyms	IL-1 Receptor Type I; Interleukin-1 Receptor Type I; RI; Interleukin-1 Receptor α CD121a; CD121 Antigen-like Family Member A
Product Type	Protein
Properties
Source/Host	HEK 293 cells
Sequence	Human IL-1RI (interleukin-1 receptor type I) (aa 21-336) is fused at the C-terminus to the Fc portion of human IgG1.
Crossreactivity	Human
Specificity	Binds to human IL-1β.
Biological Activity	Blocks IL-1β activity.
MW	~80kDa (SDS-PAGE)
Purity	≥95% (SDS-PAGE)
Endotoxin Content	<0.1EU/μg purified protein (LAL test; Lonza).
Concentration	1mg/ml after reconstitution.
Reconstitution	Reconstitute with 50μl sterile water.
Formulation	Lyophilized. Contains PBS.
Protein Negative Control	Fc (human) IgG1 Control (rec.)
Other Product Data	UniProt link P14778: IL-1 Receptor Type I (human)
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability	Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

IL-1RI is the receptor for interleukin-1α (IL-1A), β (IL-1B) and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-κB. Signaling involves formation of a ternary complex containing IL1RAP, leading the activation of TOLLIP, MYD88 and IRAK1 or IRAK2.

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IL-1R1 (human):Fc (human) (rec.)