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AdipoGen Life Sciences
Clusterin (nuclear form) (human) (rec.) (His)
380
CHF
CHF 380.00
In stock
AG-40A-0047-C05050 µgCHF 380.00
| Product Details | |
|---|---|
| Synonyms | TRPM-2; Apolipoprotein J; APO-J; CLI; CLU; SGP-2 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human nuclear clusterin (aa 23-449) is fused at the C-terminus to a His-tag. |
| Crossreactivity | Human |
| MW | ~45kDa (SDS-PAGE) |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <1EU/μg purified protein (LAL test; Lonza). |
| Concentration | 1mg/ml |
| Formulation | Liquid. 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. |
| Other Product Data | UniProt link P10909: Clusterin (human) [Precursor] |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80-kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.
Product References
- Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-κB pathways in monocytes/macrophages: Y-J. Shim, et al.; J. Leuk. Biol. 90, 761 (2011)
- Clusterin Induces MUC5AC Expression via Activation of NF-κB in Human Airway Epithelial Cells: C.H. Bae, et al.; Clin. Exp. Otorhinolaryngol. 11, 124 (2018)
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