AdipoGen Life Sciences

SIGIRR (human):Fc (human) (rec.)

CHF 170.00
In stock
AG-40A-0093T-C01010 µgCHF 170.00
AG-40A-0093T-C05050 µgCHF 350.00
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Product Details
Synonyms Toll/Interleukin-1 Receptor 8; TIR8; Single Ig IL-1R-related Molecule
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence

Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.

Crossreactivity Human
MW ~50kDa (SDS-PAGE)
Purity ≥90% (SDS-PAGE)
Endotoxin Content <0.06EU/μg purified protein (LAL test; Lonza).
Concentration After reconstitution:
for 10µg size: 0.1mg/ml
for 50µg size: 1 mg/ml
Reconstitution 10µg size: Reconstitute with 100µl sterile water.
50µg size: Reconstitute with 50µl sterile water.
Accession Number AAH03591.1
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

NCBI link AAH03591.1: SIGIRR (human)

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.

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