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AdipoGen Life Sciences
FTO (human) (rec.) (His)
265
CHF
CHF 265.00
In stock
AG-40A-0112-C01010 µgCHF 265.00
AG-40A-0112-C05050 µgCHF 625.00
| Product Details | |
|---|---|
| Synonyms | Fat Mass and Obesity-associated Protein; FATSO |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence |
Human FTO (aa 2-505) is fused at the N-terminus to a His-tag. |
| Crossreactivity | Human |
| MW | ~65kDa (SDS-PAGE) |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <1EU/μg purified protein (LAL test; Lonza). |
| Concentration | See on label. |
| Formulation | Liquid. 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. |
| Other Product Data |
UniProt link Q9C0B1: FTO (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
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