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AdipoGen Life Sciences
IL-38 (human) (rec.) (His)
260
CHF
CHF 260.00
In stock
AG-40A-0191Y-C01010 µgCHF 260.00
AG-40A-0191Y-30103 x 10 µgCHF 520.00
Figure 1: NH2-terminal sequence analysis.
| Product Details | |
|---|---|
| Synonyms | Interleukin-38; Interleukin-1 Family Member 10 theta; IL-1F10; FIL1 theta; FKSG75; IL-1HY2; IL1-theta; Interleukin-1 HY2; Interleukin-1 Receptor Antagonist FKSG75 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence |
Human IL-38 (aa 1-152) is fused at the C-terminus to a His-tag. |
| Crossreactivity | Human |
| MW | ~18kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Purified using Ni-NTA column and FPLC. |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test). |
| Concentration | 0.1 mg/ml (after reconstitution) |
| Reconstitution | Reconstitute with 100 µl endotoxin-free water. |
| Accession Number | Q8WWZ1 |
| Formulation | Lyophilized. In 50mM TRIS-Cl, pH 8.0, containing 150mM NaCl. |
| Other Product Data |
UniProt link Q8WWZ1: IL-38 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. After reconstitution, prepare aliquots and store at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36α, IL-36β or IL-36γ) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.
Product References
- Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses: J. Mora, et al.; J. Mol. Cell Biol. 8, 426 (2016)
- Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes: D. Talabot-Ayer, et al.; PLoS One 14, e0225782 (2019)
- Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma: X. Sun, et al.; Cell Mol. Immunol. 17, 631 (2020)
- Elevated IL-38 inhibits IL-23R expression and IL-17A production in thyroid-associated ophthalmopathy: Y. Pan, et al.; Int. Immunopharmacol. 91, 107300 (2021)
- Multifaceted roles of IL-38 in inflammation and cancer: A. Diaz-Barreiro, et al.; Cytokine 151, 155808 (2022)
- IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation: J.P. Dowling, et al.; MABS 15, 2212673 (2023)
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