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AdipoGen Life Sciences
Fn14 (human):Fc (human) (rec.)
300
CHF
CHF 300.00
In stock
AG-40B-0034-C05050 µgCHF 300.00
AG-40B-0034-30503 x 50 µgCHF 600.00
| Product Details | |
|---|---|
| Synonyms | Tumor Necrosis Factor Receptor Superfamily Member 12A; FGF-inducible 14; Tweak-receptor; CD266; TNFRSF12A |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1. |
| Crossreactivity |
Human Mouse |
| Specificity |
Binds to mouse and human TWEAK. |
| MW | ~35kDa (SDS-PAGE). |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.1EU/μg purified protein (LAL test; Lonza). |
| Concentration | 1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 50μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
UniProt link Q9NP84: FN14 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-κB) pathway. The TWEAK–Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.
Product References
- No evidence that soluble TACI induces signalling via membrane-expressed BAFF and APRIL in myeloid cells: J. Nys, et al.; PLoS One 8, e61350 (2013)