AdipoGen Life Sciences

CD137 (human):Fc (human) (rec.)

CHF 310.00
In stock
AG-40B-0060-C05050 µgCHF 310.00
AG-40B-0060-30503 x 50 µgCHF 625.00
More Information
Product Details
Synonyms 4-1BB; TNFRSF9
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence

The cysteine-rich region of human CD137 (aa 1-186) is fused to the Fc portion of human IgG1.

Crossreactivity Human
Specificity

Binds to human CD137L (4-1BBL).

MW ~50kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration 1mg/ml after reconstitution.
Reconstitution Reconstitute with 50μl sterile water.
Formulation Lyophilized. Contains PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

UniProt link Q07011: CD137 (human) (precursor)

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

CD137 (4-1BB) is a member of the tumor necrosis factor (TNF) receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumors in mice.

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