TACI (human):Fc (human) (rec.)
|Synonyms||TNFRSF 13B; Tumor Necrosis Factor Receptor Superfamily Member 13B; Transmembrane Activator and CAML interactor; CD267|
|Source/Host||HEK 293 cells|
The extracellular domain of human TACI (aa 2-118) is fused at the C-terminus to the Fc portion of human IgG1.
Binds to human and mouse BAFF and APRIL.
Inhibits BAFF and APRIL activity.
|Endotoxin Content||<0.01EU/μg purified protein (LAL test; Lonza).|
|Concentration||1mg/ml after reconstitution.|
|Reconstitution||Reconstitute with 50μl sterile water.|
|Formulation||Lyophilized. Contains PBS.|
|Protein Negative Control|
|Other Product Data||
UniProt link O14836: TACI (human)
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
B-cell activating factor belonging to the TNF family receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) play critical functions in promoting B-cell survival by engaging the ligands a proliferation-inducing ligand (APRIL) and/or BAFF. TACI is predominantly expressed on peripheral blood B cells and interacts with the B cell activating factor (BAFF) of ligands and a proliferation inducing ligand (APRIL), which are expressed by numerous cell types, including dendritic cells, macrophages and neutrophils. TNFRSF13B, the gene, which encodes TACI is mutated in nearly 10% of patients with common variable immune deficiency (CVID), an antibody deficiency syndrome characterized by loss of memory B cells and plasma cells.
- Selective APRIL blockade delays systemic lupus erythematosus in mouse: B. Huard, et al.; PLoS One 7, e31837 (2012)
- No evidence that soluble TACI induces signalling via membrane-expressed BAFF and APRIL in myeloid cells: J. Nys, et al.; PLoS One 8, e61350 (2013)
- Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis: H.-Y. Huang, et al.; PNAS 115, E6826 (2018)