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AdipoGen Life Sciences
RANK (mouse):Fc (human) (rec.)
290
CHF
CHF 290.00
In stock
AG-40B-0092-C05050 µgCHF 290.00
AG-40B-0092-30503 x 50 µgCHF 575.00
| Product Details | |
|---|---|
| Synonyms | TNFRSF11A; ODFR; Osteoclast Differentiation Factor Receptor; CD265 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
Mouse RANK (aa 31-214) is fused at the C-terminus to the Fc portion of human IgG1. |
| Crossreactivity |
Human Mouse |
| Specificity |
Binds to mouse and human RANKL. |
| Biological Activity |
Inhibits mouse and human RANKL biological functions. |
| MW | ~55kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test; Lonza). |
| Concentration | 1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 50μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
Uni-Prot link O35305: RANK (mouse) (precursor) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
RANK (TRANCE-R; CD265) is the receptor for RANKL/TRANCE/OPGL. It is essential for RANKL-mediated osteoclastogenesis and is involved in the regulation of interactions between T cells and dendritic cells.
Product References
- RANKL signaling sustains primary tumor growth in genetically engineered mouse models of lung adenocarcinoma: J. Faget, et al.; J. Thoracic Oncol. 13, 387 (2017)
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