IDO1 (human) Enzyme+Inhibitor Set
|Synonyms||Indoleamine 2,3-dioxygenase; INDO; IDO|
|Application Set||Compound Screening|
1x50µg of IDO1 (human) (rec.) (His) (highly active) (Prod. No. AG-40B-0161)
1x100µg of MMG-0358 (Prod. No. AG-CR1-3630)
Download our online Assay Procedure/Protocol.
|Shipping and Handling|
|Short Term Storage||-20°C|
|Long Term Storage||-20°C|
After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
|Use/Stability||Stable for at least 6 months after receipt when stored at -20°C.|
|Assay Procedure||Download PDF|
|Product Specification Sheet|
IDO1 is a heme-containing enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO1 is an immune checkpoint protein, that plays a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity.
The IDO1 (human) Enzyme+Inhibitor Set contains the active enzyme IDO1 (human) (rec.) (His) (AG-40B-0161), compound MMG-0358 (AG-CR1-3630), a very potent and specific inhibitor of IDO1, and protocols that can be used for IDO1 enzyme activity and IDO1 inhibition experiments.
Both components can be used in vitro:
• For cell culture to study the effect of hIDO1 in a cellular system.
• For screening assay to search for new inhibitors of hIDO1.