Adiponectin (mouse) ELISA Kit

CHF 590.00
In stock
AG-45A-0004YEK-KI0196 wellsCHF 590.00
AG-45A-0004YTP-KI012 x 96 wellsCHF 990.00
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Product Details
Synonyms ACRP30; AdipoQ; apM1; GBP28; Adipocyte Complement Related Protein of 30kDa
Product Type Kit
Properties
Application Set Quantitative ELISA
Specificity Detects mouse adiponectin. Does not cross-react with human adiponectin, rat adiponectin, mouse resistin, mouse RELM-β or mouse leptin.
Crossreactivity Mouse
Quantity 1 x 96 wells
2 x 96 wells (Twin Plex)
Sensitivity 50pg/ml
Range 0.125 to 8ng/ml
Sample Type Cell Culture Supernatant
Plasma
Serum
Assay Type Sandwich
Detection Type Colorimetric
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice After standard reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Plate and reagents should reach room temperature before use.
Use/Stability 12 months after the day of manufacturing. See expiry date on ELISA Kit box.
Documents
Manual Download PDF
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Adiponectin [ACRP30; AdipoQ] is a promising biomarker of insulin resistance and type 2 diabetes mellitus (T2DM) but also as a potential target for management of the metabolic syndrome. It is a very robust marker that is not prone to degradation or acute inflammatory challenges, is present in relatively high concentrations in the peripheral circulation, and can be collected by a variety of methods. The benefits of using adiponectin assays in clinical settings include, (a) prediction of risk of diabetes and metabolic status and (b) providing a tool to monitor metabolic improvements. Adiponectin exerts anti-atherogenic and anti-inflammatory properties and may be important as a biomarker for obesity-related cardiovascular disease (CVD). New findings showed urinary adiponectin excretion as an independent new biomarker of microvascular and macrovascular damage in T2DM and suggested it as a very promising tool for early cardiovascular disease risk assessment. Adiponectin serum level was also described as a good biomarker of colorectal adenoma, this being related to the positive correlation between obesity and increased risk of cancer at various sites (colorectal, breast, prostate and endometrium).

Product References
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  2. Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by highcalorie diet: S. Otabe, et al.; Am. J. Physiol. Endocrinol. Metab. 293, E210 (2007)
  3. Resveratrol inhibits TNF-α-induced changes of adipokines in 3T3-L1 adipocytes: J. Ahn, et al.; BBRC 364, 972 (2007)
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  5. Anti-diabetic Effects of Compound K versus Metformin versus Compound K-Metformin Combination Therapy in Diabetic db/db Mice: S.H. Yoon, et al.; Biol. Pharm. Bull. 30, 2196 (2007)
  6. Compound K Enhances Insulin Secretion with Beneficial Metabolic Effects in db/db Mice: G.C. Han, et al.; J. Agric. Food Chem. 55, 10641 (2007)
  7. Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes: M. Kobayashi, et al.; Endocrinology 149, 5662 (2008)
  8. A Vinegar-processed Ginseng Radix (Ginsam) Ameliorates Hyperglycemia and Dyslipidemia in C57BL/KsJ db/db Mice: E.J. Han, et al.; Food Sci. Biotechnol. 17, 1228 (2008)
  9. Effects of adiponectin transgenic expression in liver of nonalcoholic steatohepatitis model mice: H. Nakayama, et al.; Metabolism 58, 901 (2009)
  10. Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus: M.H. Nan, et al.; J. Drug Target. 18, 67 (2010)
  11. ER stress in adipocytes inhibits insulin signaling, represses lipolysis, and alters the secretion of adipokines without inhibiting glucose transport: L. Xu, et al.; Horm. Metab. Res. 42, 643 (2010)
  12. Feeding silk protein hydrolysates to C57BL/KsJ-db/db mice improves blood glucose and lipid profiles: E.Y. Jung, et al.; Nutr. Res. 30, 783 (2010)
  13. Hyperadiponectinemia enhances bone formation in mice: Y. Mitsui, et al.; BMC Musculoskelet. Disord. 12, 18 (2011)
  14. A promising culture model for analyzing the interaction between adipose tissue and cardiomyocytes: M. Anan, et al.; Endocrinology 152, 1599 (2011)
  15. Hyperadiponectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation: S. Otabe, et al.; J. Endocrinol. 213, 67 (2012)
  16. Effects of Combining Linagliptin Treatment with BI-38335, A Novel SGLT2 Inhibitor, on Pancreatic Islet Function and Inflammation in db/db Mice: L. Chen, et al.; Curr. Mol. Med. 12, 995 (2012)
  17. Chitooligosaccharide ameliorates diet-induced obesity in mice and affects adipose gene expression involved in adipogenesis and inflammation: E.H. Choi, et al.; Nutr. Res. 32, 218 (2012)
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  19. Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction: Y. Liu, et al.; Am. J. Physiol. Endocrinol. Metab. 306, E975 (2014)
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