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AdipoGen Life Sciences
Adiponectin (mouse) ELISA Kit
480
CHF
CHF 480.00
In stock
AG-45A-0004YEK-KI0196 wellsCHF 480.00
AG-45A-0004YTP-KI012 x 96 wellsCHF 870.00
Figure 1: Standard curve
| Product Details | |
|---|---|
| Synonyms | ACRP30; AdipoQ; apM1; GBP28; Adipocyte Complement Related Protein of 30kDa |
| Product Type | Kit |
| Properties | |
| Application Set | Quantitative ELISA |
| Specificity | Detects mouse adiponectin. Does not cross-react with human adiponectin, rat adiponectin, mouse resistin, mouse RELM-β or mouse leptin. |
| Crossreactivity | Mouse |
| Quantity |
1 x 96 wells 2 x 96 wells (Twin Plex) |
| Sensitivity | 50pg/ml |
| Range | 0.125 to 8ng/ml |
| Sample Type |
Cell Culture Supernatant Plasma Serum |
| Assay Type | Sandwich |
| Detection Type | Colorimetric |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use. |
| Use/Stability | 12 months after the day of manufacturing. See expiry date on ELISA Kit box. |
| Documents | |
| Manual |
 Download PDF |
| MSDS |
Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Adiponectin [ACRP30; AdipoQ] is a promising biomarker of insulin resistance and type 2 diabetes mellitus (T2DM) but also as a potential target for management of the metabolic syndrome. It is a very robust marker that is not prone to degradation or acute inflammatory challenges, is present in relatively high concentrations in the peripheral circulation, and can be collected by a variety of methods. The benefits of using adiponectin assays in clinical settings include, (a) prediction of risk of diabetes and metabolic status and (b) providing a tool to monitor metabolic improvements. Adiponectin exerts anti-atherogenic and anti-inflammatory properties and may be important as a biomarker for obesity-related cardiovascular disease (CVD). New findings showed urinary adiponectin excretion as an independent new biomarker of microvascular and macrovascular damage in T2DM and suggested it as a very promising tool for early cardiovascular disease risk assessment. Adiponectin serum level was also described as a good biomarker of colorectal adenoma, this being related to the positive correlation between obesity and increased risk of cancer at various sites (colorectal, breast, prostate and endometrium).
Product References
- Chop-deficient mice showed increased adiposity but no glucose intolerance: Y. Ariyama, et al.; Obesity 15, 1647 (2007)
- Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by highcalorie diet: S. Otabe, et al.; Am. J. Physiol. Endocrinol. Metab. 293, E210 (2007)
- Resveratrol inhibits TNF-α-induced changes of adipokines in 3T3-L1 adipocytes: J. Ahn, et al.; BBRC 364, 972 (2007)
- Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis: H. Nakayama, et al.; Metabolism 56, 470 (2007)
- Anti-diabetic Effects of Compound K versus Metformin versus Compound K-Metformin Combination Therapy in Diabetic db/db Mice: S.H. Yoon, et al.; Biol. Pharm. Bull. 30, 2196 (2007)
- Compound K Enhances Insulin Secretion with Beneficial Metabolic Effects in db/db Mice: G.C. Han, et al.; J. Agric. Food Chem. 55, 10641 (2007)
- Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes: M. Kobayashi, et al.; Endocrinology 149, 5662 (2008)
- A Vinegar-processed Ginseng Radix (Ginsam) Ameliorates Hyperglycemia and Dyslipidemia in C57BL/KsJ db/db Mice: E.J. Han, et al.; Food Sci. Biotechnol. 17, 1228 (2008)
- Effects of adiponectin transgenic expression in liver of nonalcoholic steatohepatitis model mice: H. Nakayama, et al.; Metabolism 58, 901 (2009)
- Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus: M.H. Nan, et al.; J. Drug Target. 18, 67 (2010)
- ER stress in adipocytes inhibits insulin signaling, represses lipolysis, and alters the secretion of adipokines without inhibiting glucose transport: L. Xu, et al.; Horm. Metab. Res. 42, 643 (2010)
- Feeding silk protein hydrolysates to C57BL/KsJ-db/db mice improves blood glucose and lipid profiles: E.Y. Jung, et al.; Nutr. Res. 30, 783 (2010)
- Hyperadiponectinemia enhances bone formation in mice: Y. Mitsui, et al.; BMC Musculoskelet. Disord. 12, 18 (2011)
- A promising culture model for analyzing the interaction between adipose tissue and cardiomyocytes: M. Anan, et al.; Endocrinology 152, 1599 (2011)
- Hyperadiponectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation: S. Otabe, et al.; J. Endocrinol. 213, 67 (2012)
- Effects of Combining Linagliptin Treatment with BI-38335, A Novel SGLT2 Inhibitor, on Pancreatic Islet Function and Inflammation in db/db Mice: L. Chen, et al.; Curr. Mol. Med. 12, 995 (2012)
- Chitooligosaccharide ameliorates diet-induced obesity in mice and affects adipose gene expression involved in adipogenesis and inflammation: E.H. Choi, et al.; Nutr. Res. 32, 218 (2012)
- Anti-Hyperglycemic Effect of Fermented Ginseng in Type 2 Diabetes Mellitus Mouse Model: W.J. Jeon, et al.; Phytother. Res. 27, 166 (2013)
- Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction: Y. Liu, et al.; Am. J. Physiol. Endocrinol. Metab. 306, E975 (2014)
- Relation of circulating adiponectin level with epicardial adipose tissue thickness among overweight and obese indian patients: A cross sectional study: A.M. Chakraborty, et al.; Acta Sci. Med. Sci. 4, (2020)
- Myeloid Cell–Specific IL-4 Receptor Knockout Partially Protects from Adipose Tissue Inflammation: J. Ackermann, et al.; J. Immunol. 207, 3081 (2021)
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