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Angiopoietin-like Protein 3; Angiopoietin-5; ANG-5
Product Type
Kit
Properties
Application Set
Quantitative ELISA
Specificity
Detects human ANGPTL3. Does not cross-react with mouse ANGPTL3, human ANGPTL4, human ANGPTL6, human ANGPTL7 or human ANGPTL2.
Crossreactivity
Human
Quantity
1 x 96 wells
Sensitivity
75pg/ml
Range
0.156 to 10ng/ml
Sample Type
Cell Culture Supernatant Plasma Serum
Assay Type
Sandwich
Detection Type
Colorimetric
Shipping and Handling
Shipping
BLUE ICE
Short Term Storage
+4°C
Long Term Storage
+4°C
Handling Advice
After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use.
Use/Stability
12 months after the day of manufacturing. See expiry date on ELISA Kit box.
Seven proteins containing an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristics of angiopoietins, have been identified and therefore designated angiopoietin-like proteins 1-7 (ANGPTL 1-7). ANGPTL3 and ANGPTL6 (Angiopoietin-related growth factor; AGF), among others, function to regulate angiogenesis and also appear to directly regulate lipid, glucose, and energy metabolism. ANGPTL3 plasma levels are increased in a mouse model of diabetes mellitus.
Product References
Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease: E.B. Beck, et al.; Eur. J. Prev. Cardiol. 19, 412 (2012)
Characterization of three kindreds with familial combined hypolipidemia caused by loss-of-function mutations of ANGPTL3: L. Pisciotta, et al.; Circ. Cardiovasc. Gent. 5, 42 (2012)
Atypical angiopoietin-like protein that regulates ANGPTL3: F. Quagliarini, et al.; PNAS 109, 19751 (2012)
Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis: I. Minicocci, et al.; J. Lipid Res. 54, 3481 (2013)
Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLos One 9, e99785 (2014)
Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels: G. Grammatikos, et al.; Int. J. Mol. Sci. 17, 922 (2016)
ANGPTL3 and ANGPTL8 in Thai subjects with hyperalphalipoproteinemia and severe hypertriglyceridemia: C. Kaewkrasaesin, et al.; J. Clin. Lipidol. 15, 752 (2021)
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