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AdipoGen Life Sciences
Vaspin (human) ELISA Kit
610
CHF
CHF 610.00
In stock
AG-45A-0017YEK-KI0196 wellsCHF 610.00
AG-45A-0017YTP-KI012 x 96 wellsCHF 1'100.00
Figure 1: Standard Curve
| Product Details | |
|---|---|
| Synonyms | Visceral Adipose Tissue-derived Serine Protease Inhibitor; Serpin A12; OL-64 |
| Product Type | Kit |
| Properties | |
| Application Set | Quantitative ELISA |
| Specificity | Detects human vaspin. Does not cross-react with human RBP4, human adiponectin, human Nampt, human leptin or human RELM-β. |
| Crossreactivity | Human |
| Quantity |
1 x 96 wells 2 x 96 wells (Twin Plex) |
| Sensitivity | 12pg/ml |
| Range | 0.016 to 1ng/ml |
| Sample Type |
Cell Culture Supernatant Plasma Serum |
| Assay Type | Sandwich |
| Detection Type | Colorimetric |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice |
After standard reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Plate and reagents should reach room temperature before use. |
| Use/Stability | 12 months after the day of manufacturing. See expiry date on ELISA Kit box. |
| Documents | |
| Manual |
 Download PDF |
| MSDS |
Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Vaspin (Visceral adipose tissue-derived serpin; Serpin A12), a serine protease inhibitor (serpin), is an insulin-sensitizing adipocytokine that has been isolated from both visceral and subcutaneous white adipose tissue. Based on recent findings, vaspin is suggested to regulate immune responses and inflammation and was found to be correlated with various metabolic parameters. Human vaspin blood levels are significantly increased in type 2 diabetes mellitus and obese patients. Thus vaspin may represent a novel biomarker for obesity and impaired insulin sensitivity and might serve as a new therapeutic target of metabolic syndrome.
Product References
- Serum vaspin concentrations in human obesity and type 2 diabetes: B.S. Youn, et al.; Diabetes 57, 372 (2008)
- Serum levels of the adipokine vaspin in relation to metabolic and renal parameters: J. Seeger, et al.; J. Clin. Endocrinol. Metab. 93, 247 (2008)
- Metformin decreases the Adipokine Vaspin in overweight women with the polycystic ovary syndrome: Concomitant improvement in insulin sensitivity and a decrease in insulin resistance: B.K. Tan, et al.; Diabetes 57, 1501 (2008)
- Vaspin: a novel serpin with insulin-sensitizing effects: J. Wada; Expert Opin. Investig. Drugs 17, 327 (2008)
- Vaspin serum concentrations in patients with carotid stenosis: G. Aust, et al.; Atherosclerosis 204, 262 (2009)
- Serum vaspin levels in type 2 diabetic women in relation to microvascular complications: N.E. Gulcelik, et al.; Eur. J. Endocrinol. 160, 65 (2009)
- Serum Visceral Adipose Tissue–Derived Serine Protease Inhibitor Concentrations in Human Obesity and Polycystic Ovary Syndrome: H.F. Escobar-Morreale, et al.; Diabetes Care 32, e6 (2009)
- Low-dose pioglitazone and low-dose flutamide added to metformin and oestro-progestagens for hyperinsulinaemic women with androgen excess: add-on benefits disclosed by a randomized double-placebo study over 24 months: L. Ibanez, et al.; Clin. Endocrinol. (Oxf) 71, 351 (2009)
- Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia: H. Stepan, et al.; Metabolism 59, 1054 (2010)
- Circadian Rhythm of Serum Vaspin in Healthy Male Volunteers: Relation to Meals: E. Jeong, et al.; J. Clin. Endocrinol. Metab. 95, 1869 (2010)
- Serum Vaspin Concentrations in Relation to Insulin Sensitivity Following RYGB-Induced Weight Loss: A. Handisurya, et al.; Obes. Surg. 20, 198 (2010)
- Serum chemerin and vaspin in non-alcoholic fatty liver disease: M. Kukla, et al.; Scand. J. Gastroenterol. 45, 235 (2010)
- Chemerin, vaspin and insulin resistance in chronic hepatitis C: M. Kukla, et al.; J. Viral Hepat. 17, 661 (2010)
- Combined effects of body mass index and cardio/respiratory fitness on serum vaspin concentrations in Korean young men: J.K. Chou, et al.; Eur. J. Appl.Physiol. 108, 347 (2010)
- Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects: H.M. Chang, et al.; Metabolism 59, 1276 (2010)
- Reduced serum vaspin concentrations in obese children following shortterm intensive lifestyle modification: M.K. Lee, et al.; Clin. Chim. Acta 411, 381 (2010)
- Effects of weight reduction on serum vaspin concentrations in obese subjects: modification by insulin resistance: H.M. Chang, et al.; Obesity (Silver Spring) 18, 2105 (2010)
- Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans: C. von Loeffelholz, et al.; Eur. J. Endocrinol. 162, 507 (2010)
- Vaspin and omentin: new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis: L. Senolt, et al.; Ann. Rheum. Dis. 69, 1410 (2010)
- Comparison of orlistat treatment and placebo in obese type 2 diabetic patients: G. Derosa, et al.; Expert. Opin. Pharmacother. 11, 1971 (2010)
- Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients: G. Derosa, et al.; Fundam. Clin. Pharmacol. 25, 642 (2011)
- Vaspin and visfatin/Nampt are interesting interrelated adipokines playing a role in the pathogenesis of type 2 diabetes mellitus: H.O. El-Mesallamy, et al.; Metabolism 60, 63 (2011)
- Effects of combination of sibutramine and l-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients: G. Derosa, et al.; Metabolism 60, 421 (2011)
- Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism: G.A. Martos-Moreno, et al.; Int. J. Obes. (Lond) 35, 1355 (2011)
- Omentin-1 and vaspin are present in the fetus and neonate, and perinatal concentrations are similar in normal and growth-restricted pregnancies: D.D. Briana, et al.; Metabolism 60, 486 (2011)
- Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children: A. Körner, et al.; Int. J. Obes. (Lond) 35, 578 (2011)
- Different actions of losartan and ramipril on adipose tissue activity and vascular remodeling biomarkers in hypertensive patients: G. Derosa, et al.; Hypertens. Res. 34, 145 (2011)
- Lifestyle modification increases circulating adiponectin concentrations but does not change vaspin concentrations: S.M. Kim, et al.; Metabolism 60, 1294 (2011)
- Adipokine profile is modulated in subcutaneous adipose tissue by TNF{alpha} inhibitors in patients with rheumatoid arthritis: L. Senolt, et al.; Ann. Rheum. Dis. 70, 2054 (2011)
- New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women: T. Auguet, et al.; BMC Med. Genet. 12, 60 (2011)
- Serum vaspin and C-reactive protein levels in women with polycystic ovaries and polycystic ovary syndrome: E. Cakal, et al.; Gynecol. Endocrinol. 27, 491 (2011)
- Serum vaspin levels in hypothyroid patients: N. Cinar, et al.; Eur. J. Endocrinol. 165, 563 (2011)
- Correlation of Circulating Omentin-1 with Bone Mineral Density in Multiple Sclerosis: The Crosstalk between Bone and Adipose Tissue: M. Assadi, et al.; PLoS One 6, e24240 (2011)
- Vaspin plasma concentrations and mRNA expressions in patients with stable and unstable angina pectoris: H.L. Li, et al.; Clin. Chem. Lab. Med. 49, 1547 (2011)
- Short-term effect of weight loss through restrictive bariatric surgery on serum levels of vaspin in morbidly obese subjects: A. Golpaie, et al.; Eur. Cytokine Netw. 22, 181 (2011)
- Association between hepatic angiogenesis and serum adipokine profile in non-obese chronic hepatitis C patients: M. Kukla, et al.; Pol. J. Pathol. 62, 218 (2011)
- Circulating levels of the adipocytokines vaspin and omentin in patients with Kawasaki disease: A. Fioravanti, et al.; Rheumatol. Int. 32, 1481 (2012)
- Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention: M. Blüher, et al.; Diabetes Care 35, 342 (2012)
- Increased levels and adipose tissue expression of visfatin in morbidly obese women. The relationship with pro-inflammatory cytokines: X. Terra, et al.; Clin. Endocrinol. (Oxf.) 77, 691 (2011)
- Treatment-specific changes in circulating adipocytokines: a comparison between tumour necrosis factor blockade and glucocorticoid treatment for rheumatoid arthritis: R. Klaasen, et al.; Ann. Rheum. Dis. 71, 1510 (2012)
- The Impact of Type 2 Diabetes on Circulating Adipokines in Patients with Metabolic Syndrome: K. Schindler, et al.; Obes. Facts 5, 270 (2012)
- Vaspin-a link of obesity and psoriasis?: A. Saalbach, et al.; Exp. Dermatol. 21, 309 (2012)
- Post-Resistance Exercise Response of Vaspin Adipocytokin and its Relation to Insulin and Glucose Levels in Overweight Women: M. Ghahramani, et al.; Middle-East J. Sci. Res. 11, 1328 (2012)
- Genetic variation in the vaspin gene affects circulating serum vaspin concentrations: J. Breitfeld, et al.; Int. J. Obes. 37, 861 (2013)
- Association of vaspin gene polymorphisms with coronary artery disease in Chinese population and function study: H.L. Li, et al.; Clin. Chim. Acta. 415, 233 (2013)
- Vaspin concentration in obesity, impaired glucose tolerance and Type 2 diabetes in Egypt: H.B. Atya, et al.; Adv. Res. Biol. Sci. 1, 6 (2013)
- Associations between tissue visfatin/nicotinamide, phosphoribosyltransferase (Nampt), retinol binding protein-4, and vaspin concentrations and insulin resistance in morbidly obese subjects: Z. Goktas, et al.; Mediators Inflamm. 2013, 861496 (2013)
- Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation: G. Flehmig, et al.; PLoS One 9, e99785 (2014)
- Expression of vaspin in the joint and the levels in the serum and synovial fluid of patients with osteoarthritis: J.-P. Bao, et al.; Int. J. Clin. Exp. Med. 7, 3447 (2014)
- Association of vaspin with metabolic syndrome: The pivotal role of insulin resistance: A. Esteghmatai, et al.; Diabet. Metab. 38, 143 (2014)
- Serum Vaspin Levels Are Associated with the Development of Clinically Manifest Arthritis in Autoantibody-Positive Individuals: K.I. Maijer, et al.; PLoS One 10, e0144932 (2015)
- Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome: Y. Guvenc, et al.; J. Int. Med. Res. 44, 796 (2016)
- Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway: K. Zieger, et al.; Mol. Cell Endocrinol. 460, 181 (2018)
- Association of serum uromodulin with adipokines in dependence of type 2 diabetes: C. Then, et al.; Cytokine 150, 155786 (2022)
- Genetic dissection of serum vaspin highlights its causal role in lipid metabolism: J. Breitfeld, et al.; Obesity 31, 2862 (2023)
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