AdipoGen Life Sciences

Progranulin (human) ELISA Kit (mAb/mAb)

CHF 610.00
In stock
AG-45B-0027-KI0196 wellsCHF 610.00
More Information
Product Details
Synonyms Acrogranin; Epithelin Precursor; Glycoprotein of 88 Kda; GP88; Glycoprotein 88; Granulin Precursor; PC Cell-derived Growth Factor; PCDGF; Proepithelin; PEPI
Product Type Kit
Properties
Application Set Quantitative ELISA
Specificity

Detects human progranulin in cell culture supernatants, serum and plasma and allows the detection of Progranulin FTLD mutations.

Crossreactivity Human
Quantity

1 x 96 wells

Sensitivity 60pg/ml
Range 0.063 to 4ng/ml
Sample Type Cell Culture Supernatant
Plasma
Serum
Assay Type Sandwich
Detection Type Colorimetric
Other Product Data

Uniprot link P28799: Progranulin (human)

Accession Number P28799
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice After standard reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Plate and reagents should reach room temperature before use.
Use/Stability 12 months after the day of manufacturing. See expiry date on ELISA Kit box.
Documents
Manual Download PDF
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Progranulin (PGRN) is a widely expressed pluripotent growth factor that plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. In addition, PGRN has also been linked to tumorigenesis. New cutting-edge publications have shown that progranulin might be a biomarker not only for FTLD but also for other types of Alzheimer‘s disease (AD). This new data even suppose the potential of progranulin to be a biomarker for MCI (Mild Cognitive Impairment), which would be a hallmark in AD research. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory diseases like arthritis.

Mutations in PGRN have been found to be a common cause of familial frontotemporal lobar degeneration called FTLD. Since Progranulin has neurotrophic properties and most mutations are predicted to result in a heterozygous loss of gene expression, PGRN deficiency so-called haploinsufficiency is thought to cause neurodegeneration in these patients. GRN mutations are frequent causes of familial frontotemporal degeneration. Reduced progranulin levels in plasma or serum, constitute a reliable, cost-effective biomarker, suitable as a screening tool in patients with familial frontotemporal degeneration. The new mAb-based human Progranulin ELISA Kit has been thor­oughly validated and compared to the standard pAb-based ELISA Kit from AdipoGen (Prod. No. AG-45A-0018Y). With this new ELISA Kit, levels below 50 ng/ml are strongly suggestive of GRN mutations. In a validation on 191 patient samples, confirmed by a molecular gene analysis, the new kit provided a sensitivity and specificity of 100% for de­tecting FTLD mutations.

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