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AdipoGen Life Sciences
n-Octyl-β-D-glucopyranoside (ultrapure)
As low as
50
CHF
CHF 50.00
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AG-CC1-0008-G0011 gCHF 50.00
AG-CC1-0008-G0055 gCHF 200.00
AG-CC1-0008-G02525 gCHF 650.00
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | OG; n-Octylglucoside; n-Octyl-β-D-glucoside; BTB11967 |
| Product Type | Chemical |
| Properties | |
| Formula |
C14H28O6 |
| MW | 292.4 |
| CAS | 29836-26-8 |
| Purity Chemicals |
≥99%(HPLC) [α-Isomer <2% (NMR)] [n-Octanol: <0.005%] |
| Appearance | White powder. |
| Solubility | Soluble in water (100 mg/ml), DMSO or DMF. |
| Identity | Determined by 1H-NMR |
| InChi Key | HEGSGKPQLMEBJL-UHFFFAOYSA-N |
| Smiles | OCC1[C@@H](O)C(O)[C@H](O)[C@H](OCCCCCCCC)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Protect from light and moisture. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Scientific Background Information
Product Description
- Non-ionic detergent for the functional solubilization, isolation, purification and crystallograpy of membrane proteins.
- Mild, non-
denaturing detergent that is used for the solubilization and reconstitution of membrane- bound proteins in their native state and for the preparation of lipid vesicles. - Its well-defined chemical structure, small uniform micelles and high water solubility make it superior to most other non-ionic detergents for membrane solubilization. The high critical micelle concentration (0.7%) of n-
octylglucoside facilitates ready removal from final protein extracts by dialysis or gel filtration. - Used in lysis and solubilisation buffers for bacterial lipoprotein preparations, mitochondrial extracts or for determination of protein content by BCA assay.
- Can be used in 2D electrophoresis and to improve selectivity of immunoprecipitation of phosphotyrosine modified proteins and to increase the resolution of proteins in 2D gels.
Product-specific References
- Effects of octyl beta-glucoside on insulin binding to solubilized membrane receptors: R.J. Gould, et al.; Biochemistry 20, 6776 (1981)
- Reconstitution of Membrane Receptor Systems: A. Levitzki; Biochim. Biophys. Acta 822, 127 (1985)
- Micellar Properties of Octylglucoside in Aqueous Solutions: K. Kameyama, et al.; J. Colloid Interface Sci. 137, 1 (1990)
- Reconstitution of the sarcoplasmic reticulum Ca(2+)-ATPase: mechanisms of membrane protein insertion into liposomes during reconstitution procedures involving the use of detergents: D. Levy, et al.; Biochim. Biophys. Acta 1107, 283 (1992)
- Molecular dynamics characterization of n-octyl-beta-D-glucopyranoside micelle structure in aqueous solution: P. Konidala, et al.; J. Mol. Graph. Model 25, 77 (2006)
- Use of detergents to increase selectivity of immunoprecipitation of tyrosine phosphorylated peptides prior to identification by MALDI quadrupole-
TOF MS: G. Zhan & T.A. Neubert; Proteomics 6, 571 (2006) - Development and crystallization of a minimal thermostabilised G protein-coupled receptor: T. Warne, et al.; Protein Expr. Purif. 65, 204 (2009)
- Mass spectrometry of intact membrane protein complexes: A. Laganowsky, et al.; Nat. Protocols 8, 639 (2013)
- Low-Resolution Structure of Detergent-Solubilized Membrane Proteins from Small-Angle Scattering Data: A. Koutsioubas; Biophys. J. 113, 2373 (2017)
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