(25S)-Δ7-Dafachronic acid

CHF 300.00
In stock
AG-CN2-0014-C100100 µgCHF 300.00
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Product Details
Synonyms UPF-1404
Product Type Chemical
Properties
Formula C27H42O3
MW 414.6
CAS 949004-12-0
Purity Chemicals ≥95% (HPLC)
Appearance White to off-white solid.
Solubility Highly soluble in DMSO. Soluble in ethanol or methanol.
Only slightly soluble in water, dichloromethane or acetone.
Identity Identity determined by 1H-NMR.
InChi Key SQTAVUCHOVVOFD-AAVWLPFVSA-N
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Ligand of DAF-12, an orphan nuclear receptor, that regulates dauer diapause, reproductive development, fat metabolism, and life span (life cycle) in parasitic nematodes [1, 2, 3].
  • Sterol-derived hormone. 
  • Blocks formation of infective larvae in several parasitic nematodes [4, 5]. 
  • Inhibits the dauer-promoting activity of DAF-12 [4, 5].
  • Supports the reproductive development [4, 5].
Product References
  1. Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans: D.L. Motola, et al.; Cell 124, 1209 (2006)
  2. A Potential Biochemical Mechanism Underlying the Influence of Sterol Deprivation Stress on Caenorhabditis elegans: M.C. Cheong, et al.; JBC 286, 7248 (2011) 
  3. Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan: K.J. Dumas, et al.; Dev. Biol. 340, 605 (2010)
  4. A Conserved Endocrine Mechanism Controls the Formation of Dauer and Infective Larvae in Nematodes: A. Ogawa, et al.; Curr. Biol. 19, 67 (2009)
  5. Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes: Z. Wang, et al.; PNAS 106, 9138 (2009)
  6. Indicted: Worms Caught using Steroids: R.B. Beckstead & C.S. Thummel; Cell 124, 1137 (2006) Review
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