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AdipoGen Life Sciences
(25S)-Δ7-Dafachronic acid
350
CHF
CHF 350.00
In stock
AG-CN2-0014-C100100 µgCHF 350.00
| Product Details | |
|---|---|
| Synonyms | UPF-1404 |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H42O3 |
| MW | 414.6 |
| CAS | 949004-12-0 |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility |
Highly soluble in DMSO. Soluble in ethanol or methanol. Only slightly soluble in water, dichloromethane or acetone. |
| Identity | Identity determined by 1H-NMR. |
| InChi Key | SQTAVUCHOVVOFD-AAVWLPFVSA-N |
| Smiles | C[C@H](CCC[C@H](C)C(O)=O)[C@H]1CCC2C3=CCC4CC(=O)CC[C@]4(C)C3CC[C@]12C |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Ligand of DAF-12, an orphan nuclear receptor, that regulates dauer diapause, reproductive development, fat metabolism, and life span (life cycle) in parasitic nematodes [1, 2, 3].
- Sterol-derived hormone.
- Blocks formation of infective larvae in several parasitic nematodes [4, 5].
- Inhibits the dauer-promoting activity of DAF-12 [4, 5].
- Supports the reproductive development [4, 5].
Product References
- Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans: D.L. Motola, et al.; Cell 124, 1209 (2006)
- A Potential Biochemical Mechanism Underlying the Influence of Sterol Deprivation Stress on Caenorhabditis elegans: M.C. Cheong, et al.; JBC 286, 7248 (2011)
- Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan: K.J. Dumas, et al.; Dev. Biol. 340, 605 (2010)
- A Conserved Endocrine Mechanism Controls the Formation of Dauer and Infective Larvae in Nematodes: A. Ogawa, et al.; Curr. Biol. 19, 67 (2009)
- Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes: Z. Wang, et al.; PNAS 106, 9138 (2009)
- Indicted: Worms Caught using Steroids: R.B. Beckstead & C.S. Thummel; Cell 124, 1137 (2006) Review
- Reevaluation of whether a soma–to–germ-line transformation extends lifespan in Caenorhabditis elegans: A.K. Knutson, et al.; PNAS 133, 3591 (2016)
- Neuronal function of the mRNA decapping complex determines survival of Caenorhabditis elegans at high temperature through temporal regulation of heterochronic gene expression: F. Borbolis, et al.; Open Biol. 7, 160313 (2017)
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