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AdipoGen Life Sciences
Sauchinone
40
CHF
CHF 40.00
In stock
AG-CN2-0032-M0011 mgCHF 40.00
AG-CN2-0032-M0055 mgCHF 120.00
| Product Details | |
|---|---|
| Synonyms | 1′-Epimer dihydrocarpanone |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H20O6 |
| MW | 356.4 |
| CAS | 177931-17-8 |
| Source/Host Chemicals | Isolated from Saururus chinensis. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO or chloroform. |
| Identity | Determined by 1H-NMR. |
| InChi Key | GMTJIWUFFXGFHH-WPAOEJHSSA-N |
| Smiles | [H][C@]12C[C@@H](C)[C@H](C)[C@@]3([H])C4=C(O[C@]5(OCOC5=CC1=O)[C@@]23[H])C=C1OCOC1=C4 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Hepatoprotective antioxidant [1, 2, 9].
- Anti-inflammatory. Suppresses NF-kB p65 activity [3, 5].
- Neuroprotective. Apoptosis inhibitor [4].
- Bone resorption/osteoclastogenesis inhibitor. Reduces ROS formation [6].
- Antiseptic [7].
- AMP-activated kinase (AMPK) activator [8].
- Akt phosphorylation inhibitor [10].
- Arginase II inhibitor [11].
Product References
- Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes: S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000)
- Hepatoprotective diastereomeric lignans from Saururus chinensis herbs: S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000)
- Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation: A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003)
- Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells: H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003)
- Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB: B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003)
- Inhibition of osteoclast differentiation and bone resorption by sauchinone: K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007)
- Protective effect of lignans against sepsis from the roots of Saururus chinensis: C.S. Seo, et al.; Biol. Pharm. Bull. 31, 523 (2008)
- Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury: Y.W. Kim, et al.; Free Radic. Biol. Med. 47, 1082 (2009)
- Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway: H.Y. Kay, et al.; Br. J. Pharmacol. 163, 1653 (2011)
- Sauchinone suppresses lipopolysaccharide-induced inflammatory responses through Akt signaling in BV2 cells: E.Y. Yang, et al.; Int. Immunopharmacol. 14, 188 (2012)
- Arginase II inhibitory activity of phenolic compounds from Saururus chinensis: C. J. Lim, et al.; Bull. Korean Chem. Soc. 33, 3079 (2012)
- Pharmacokinetics and pharmacodynamics of promising Arginase Inhibitors: K.S. Abdelkawy, et al.; Eur. J. Drug Metab. Pharmacokinet. 42, 355 (2017) Review
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