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AdipoGen Life Sciences
Wogonin
80
CHF
CHF 80.00
In stock
AG-CN2-0064-M0055 mgCHF 80.00
AG-CN2-0064-M02525 mgCHF 320.00
| Product Details | |
|---|---|
| Synonyms | WOG; 5,7-Dihydroxy-8-methoxyflavone; BRN 0287152 |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H12O5 |
| MW | 284.3 |
| CAS | 632-85-9 |
| RTECS | LK8331000 |
| Source/Host Chemicals | Isolated from Scutellaria baicalensis Georgi. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO and methanol. |
| Identity | Determined by 1H-NMR and MS. |
| InChi Key | XLTFNNCXVBYBSX-UHFFFAOYSA-N |
| Smiles | COC1=C(O)C=C(O)C2=C1OC(=CC2=O)C1=CC=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anti-inflammatory. Increases nitric oxide (NO) production [1].
- Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II) [2, 5].
- Antioxidant [3].
- Anti-viral. Shows anti-hepatitis B virus activity [4].
- MCP-1 inhibitor [6].
- Shows anxiolytic effect through modulation of the GABA(A) receptor complex [7].
- Antifungal [8].
- Neuroprotective [9].
- Anticancer compound. Apoptosis and cell cycle arrest inducer [10, 12, 14, 17, 18].
- Sensitizes TNFα- and TRAIL-induced apoptosis [11, 12].
- Antiangiogenic [13].
- NF-κB inhibitor [15].
- Telomerase activity inhibitor [16].
- CDK9 inhibitor [19].
- PI3K-AKT pathway modulator [20].
- Autophagy inducer [21].
Product References
- Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages: I. Wakabayashi; Pharmacol. Toxicol. 84, 288 (1999)
- Wogonin inhibits inducible prostaglandin E(2) production in macrophages: I. Wakabayashi & K. Yasui; Eur. J. Pharmacol. 406, 477 (2000)
- Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin: D.E. Shieh, et al.; Anticancer Res. 20, 2861 (2000)
- Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis: R.L. Huang, et al.; Planta Med. 66, 694 (2000)
- Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide: Y.C. Chen, et al.; Biochem. Pharmacol. 61, 1417 (2001)
- Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells: Y.L. Chang, et al.; Mol. Pharmacol. 60, 507 (2001)
- Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi: K.M. Hui, et al.; Biochem. Pharmacol. 64, 1415 (2002)
- Antifungal activity of wogonin: M. Pal, et al.; Phytother. Res. 17, 1215 (2003)
- Neuroprotective effect of wogonin: potential roles of inflammatory cytokines: H.Z. Piao, et al.; Arch. Pharm. Res. 27, 930 (2004)
- The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo: W. Wang, et al.; Biol. Pharm. Bull. 29, 1132 (2006)
- Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis: S.C. Fas, et al.; Blood 108, 3700 (2006)
- Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells: D.H. Lee, et al.; Biochem. Pharmacol. 75, 2020 (2008)
- Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2: N. Lu, et al.; Life Sci. 82, 956 (2008)
- Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation: H.W. Zhang, et al.; Eur. J. Pharmacol. 591, 7 (2008)
- Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity: H.Z. Piao, et al.; Int. Immunopharmacol. 8, 1658 (2008)
- Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells: S.T. Huang, et al.; Phytomedicine 17, 47 (2010)
- Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells: J.S. Yu & A.K. Kim; Mol. Cells 31, 327 (2011)
- Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9: P. Chen, et al.; Toxicology 282, 122 (2011)
- Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1: G. Polier, et al.; Cell Death Dis. 2, e182 (2011)
- Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway: K.F. Huang, et al.; Int. Immunopharmacol. 12, 334 (2012)
- Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells: S.E. Chow, et al.; J. Cell Biochem. 113, 3476 (2012)
- Wogonin inhibits tight junction disruption via suppression of inflammatory response and phosphorylation of AKT/NF-κB and ERK1/2 in rhinovirus-infected human nasal epithelial cells: K. A. Kim, et al.; Inflamm. Res. ahead of print (2022)