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AdipoGen Life Sciences
Stevioside . hydrate
80
CHF
CHF 80.00
In stock
AG-CN2-0077-M01010 mgCHF 80.00
AG-CN2-0077-M05050 mgCHF 320.00
| Product Details | |
|---|---|
| Synonyms | BRN 0077427; CCRIS 6116 |
| Product Type | Chemical |
| Properties | |
| Formula |
C38H60O18 . xH2O |
| MW | 804.9 (anhydrous basis) |
| CAS | 57817-89-7 (anhydrous) |
| Source/Host Chemicals | Isolated from Stevia rebaudiana. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in water. |
| Identity | Determined by 1H-NMR. |
| Other Product Data |
Water content: 2-5% |
| InChi Key | UEDUENGHJMELGK-ZBVPAOMMSA-N |
| Smiles | [H][C@@]12CC[C@@]3(C[C@]1(CC3=C)CC[C@]1([H])[C@@](C)(CCC[C@@]21C)C(=O)O[C@@H]1OC(CO)[C@@H](O)[C@@H](O)C1O)O[C@@H]1OC(CO)[C@@H](O)[C@@H](O)C1O[C@@H]1OC(CO)[C@@H](O)[C@@H](O)C1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Hygroscopic. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Noncaloric natural sweetener, 300 times more potent than sucrose [1].
- Antidiabetic. Antihyperglycaemic and antihypoglycaemic. Potentiates insulin secretion. Enhances acetyl-CoA carboxylase (ACC) gene expression. Increases insulin sensitivity. [2, 4, 6-9, 11].
- Antihypertensive. Ca2+ influx inhibitor [3, 6].
- Anticancer compound [5].
- Chemopreventive [14].
- Anti-inflammatory. IKKβ, NF-κB and MAPK signaling inhibitor. Induces TNF-α, IL-1β and nitric oxide release [10, 17, 18].
- Immunomodulator. Increasees phagocytic activity, haemagglutination antibody titre, delayed type hypersensitivity. Increased proliferation in LPS and Con A stimulated B and T cells [12].
- Peripheral μ-opioid receptors activator. Important for regulation of glucose homeostasis [15].
- Anti-atherosclerotic [16].
- Review [13].
Product References
- Letter to the editor: stevioside, a natural sweetening agent: C. Taylor; Am. J. Clin. Nutr. 22, 4 (1969)
- Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity: P.B. Jeppesen, et al.; Metabolism 49, 208 (2000)
- Inhibitory effect of stevioside on calcium influx to produce antihypertension: C.N. Lee, et al.; Planta Med. 67, 796 (2001)
- Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats: P.B. Jeppesen, et al.; Phytomedicine 9, 9 (2002)
- Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin: K. Yasukawa, et al.; Biol. Pharm. Bull. 25, 1488 (2002)
- Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat: P.B. Jeppesen, et al.; Metabolism 52, 372 (2003)
- Antihyperglycemic effects of stevioside in type 2 diabetic subjects: S. Gregersen, et al.; Metabolism 53, 73 (2004)
- Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle: N. Lailerd, et al.; Metabolism 53, 101 (2004)
- Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana: T.H. Chen, et al.; Planta Med. 71, 108 (2005)
- Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells: C. Boonkaewwan, et al.; J. Agric. Food Chem. 54, 785 (2006)
- Stevioside improves pancreatic beta-cell function during glucotoxicity via regulation of acetyl-CoA carboxylase: J. Chen, et al.; Am. J. Physiol. Endocrinol. Metab. 292, E1906 (2007)
- Immune up regulatory response of a non-caloric natural sweetener, stevioside: I. Sehar, et al.; Chem. Biol. Interact. 173, 115 (2008)
- Stevioside and related compounds: therapeutic benefits beyond sweetness: V. Chatsudthipong & C. Muanprasat; Pharmacol. Ther. 121, 41 (2009) (Review)
- Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds: M. Takasaki, et al.; Bioorg. Med. Chem. 17, 600 (2009)
- Stimulatory effect of stevioside on peripheral mu opioid receptors in animals: P.S. Yang, et al.; Neurosci. Lett. 454, 72 (2009)
- Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice: B. Geeraert, et al.; Int. J. Obes. 34, 569 (2010)
- Stevioside ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by downregulating the NF-κB pathway: Z. Wang, et al.; BBRC 417, 1280 (2012)
- Stevioside Suppressed Inflammatory Cytokine Secretion by Downregulation of NF-κB and MAPK Signaling Pathways in LPS-Stimulated RAW264.7 Cells: L. Fengyang, et al.; Inflammation 35, 1669 (2012)