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AdipoGen Life Sciences
4α-Phorbol 12-myristate 13-acetate
90
CHF
CHF 90.00
In stock
AG-CN2-0082-M0011 mgCHF 90.00
| Product Details | |
|---|---|
| Synonyms | 4α-PMA; 4α-TPA; 4α-12-O-Tetradecanoylphorbol 13-acetate |
| Product Type | Chemical |
| Properties | |
| Formula |
C36H56O8 |
| MW | 616.8 |
| CAS | 63597-44-4 |
| Source/Host Chemicals | Semi-synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO, ehanol, methanol or ethyl acetate. |
| InChi Key | PHEDXBVPIONUQT-LQLWEASQSA-N |
| Smiles | [H][C@]12[C@]3([H])C=C(CO)C[C@@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCCCCCC)[C@@]1(OC(C)=O)C2(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Negative control for phorbol ester activation of protein kinase C and studies with PMA (AG-CN2-0010) [1-6].
- Might be a reasonable PKC-independent TRPV4 channels agonist [5].
Product References
- Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin: B.L. Van Duuren et al.; Cancer Res. 39, 2644 (1979)
- Modulation of human platelet-activating factor receptor gene expression by protein kinase C activation: M. Thivierge, et al.; J. Immunol. 157, 4681 (1996)
- Integrin ligation and PKC activation are required for migration of colon carcinoma cells: V. Rigot, et al.; J. Cell Sci. 111, 3119 (1998)
- Activated protein kinase C isoforms target to cardiomyocyte caveolae: stimulation of local protein phosphorylation: V.O. Rybin, et al.; Circ. Res. 84, 980 (1999)
- Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4: F. Xu, et al.; Br. J. Pharmacol. 140, 413 (2003)
- Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay: L. Saraiva, et al; Eur. J. Pharmacol. 491, 101 (2004)
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