4α-Phorbol 12-myristate 13-acetate

CHF 75.00
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AG-CN2-0082-M0011 mgCHF 75.00
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Product Details
Synonyms 4α-PMA; 4α-TPA; 4α-12-O-Tetradecanoylphorbol 13-acetate
Product Type Chemical
Properties
Formula

C36H56O8

MW 616.8
CAS 63597-44-4
Source/Host Chemicals Semi-synthetic.
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO, ehanol, methanol or ethyl acetate.
InChi Key PHEDXBVPIONUQT-LQLWEASQSA-N
Smiles [H][C@]12[C@]3([H])C=C(CO)C[C@@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCCCCCC)[C@@]1(OC(C)=O)C2(C)C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Negative control for phorbol ester activation of protein kinase C and studies with PMA (AG-CN2-0010) [1-6].
  • Might be a reasonable PKC-independent TRPV4 channels agonist [5].
Product References
  1. Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin: B.L. Van Duuren et al.; Cancer Res. 39, 2644 (1979)
  2. Modulation of human platelet-activating factor receptor gene expression by protein kinase C activation: M. Thivierge, et al.; J. Immunol. 157, 4681 (1996)
  3. Integrin ligation and PKC activation are required for migration of colon carcinoma cells: V. Rigot, et al.; J. Cell Sci. 111, 3119 (1998)
  4. Activated protein kinase C isoforms target to cardiomyocyte caveolae: stimulation of local protein phosphorylation: V.O. Rybin, et al.; Circ. Res. 84, 980 (1999)
  5. Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4: F. Xu, et al.; Br. J. Pharmacol. 140, 413 (2003)
  6. Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay: L. Saraiva, et al; Eur. J. Pharmacol. 491, 101 (2004)
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