AdipoGen Life Sciences


CHF 180.00
In stock
AG-CN2-0085-M01010 mgCHF 180.00
AG-CN2-0085-M100100 mgCHF 1'260.00
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Product Details
Synonyms (-)-Umbellulone; Umbellol; NSC 22046; BRN 2042730; Oreodaphnol; 3-Thujen-2-one
Product Type Chemical


MW 150.2
CAS 546-78-1
RTECS XP0200000
Source/Host Chemicals Isolated from Umbellularia californica Nutt.
Purity Chemicals ≥98% (HPLC)
Appearance Colourless oil.
Solubility Soluble in DMSO or ethanol.
Identity Determined by 1H-NMR.
Other Product Data

Irritant: Umbellulone is a headache-inducing monoterpene ketone. Can induce headache when inhaling. Caution should be taken when dealing with this substance.

Smiles CC(C)C12CC1C(C)=CC2=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Offensive principle of the so-called "headache tree".
  • Causes a painful cold sensation.
  • Selective TRPA1 activator. Weak TRPM8 activator.
  • Releases CGRP (calcitonin gene-related peptide) after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine.
Product References
  1. Umbellulone modulates TRP channels: J. Zhong, et al.; Pflugers Arch. 462, 861 (2011)
  2. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system: R. Nassini, et al.; Brain 135, 376 (2012)
  3. Activation of TRPA1 on dural afferents: a potential mechanism of headache pain: R.M. Edelmayer, et al.; Pain 153, 1949 (2012)
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