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AdipoGen Life Sciences
Heliquinomycin
370
CHF
CHF 370.00
In stock
AG-CN2-0091-C250250 µgCHF 370.00
AG-CN2-0091-C500500 µgCHF 660.00
| Product Details | |
|---|---|
| Synonyms | Rubymycin; NSC 702208 |
| Product Type | Chemical |
| Properties | |
| Formula | C33H30O17 |
| MW | 698.6 |
| CAS | 178182-49-5 |
| RTECS | WG9689000 |
| Source/Host Chemicals | Isolated from Streptomyces sp. MJ929-SF2. |
| Purity Chemicals | ≥80% (HPLC) |
| Appearance | Red powder. |
| Solubility | Soluble in DMSO, ethanol, chloroform or ethyl acetate. Insoluble in water or n-hexane. |
| Declaration | Manufactured by the Institute of Microbial Chemistry (BIKAKEN). |
| InChi Key | MLFZQFHGXSVTGX-VJANPNJTSA-N |
| Smiles | COC1CC(O[C@@H]2C3=C(O[C@@]22OC4=C(C[C@H]2O)C=C2C=C(OC(=O)C2=C4O)C(=O)OC)C(O)=C2C(=O)C(OC)=CC(=O)C2=C3O)OC(C)C1O |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic [1].
- DNA helicase inhibitor [1]. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex [3, 4].
- Topoisomerase I and II inhibitor (weaker than DNA helicase) [2].
- DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis [2].
- Induces cell cycle arrest [2].
- Anticancer compound [1, 2].
- Antibacterial against Gram-positive bacteria [1].
Product References
- Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities: M. Chino, et al.; J. Antibiot. 49, 752 (1996)
- Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth: M. Chino, et al.; J. Antibiot. 51, 480 (1998)
- Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase: Y. Ishimi, et al.; FEBS J. 276, 3382 (2009)
- Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase: T. Sugiyama, et al.; J. Biochem. 151, 129 (2012)
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