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AdipoGen Life Sciences
K-252c
90
CHF
CHF 90.00
In stock
AG-CN2-0097-M0011 mgCHF 90.00
AG-CN2-0097-M0055 mgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | Staurosporine aglycone; Staurosporinone; Antibiotic K252c; 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H13N3O |
| MW | 311.4 |
| CAS | 85753-43-1 |
| Source/Host Chemicals | Isolated from Streptomyces longisporoflavus. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Off-white to yellow crystalline solid. |
| Solubility | Soluble in DMSO or methanol. Insoluble in water. |
| InChi Key | MEXUTNIFSHFQRG-UHFFFAOYSA-N |
| Smiles | O=C1NCC2=C1C1=C(NC3=C1C=CC=C3)C1=C2C2=C(N1)C=CC=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. Stock solutions are stable for at least 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Indolocarbazole alkaloid antibiotic. [1].
- Potent cell permeable reversible and ATP-competitive PKC (protein kinase C) inhibitor with 10-fold selectivity over PKA (protein kinase A) [1-5].
- Anticancer compound. Cytotoxic againt various cancer cell lines [6, 9,11].
- Apoptosis inducer [11].
- Antiviral compound against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) [7].
- LACTB (β-lactamase), malate dehydrogenase (MDH2, MDHC, MDH1B, ME1. ME2, ME3) and chymotrypsin inhibitor [8].
- Inhibits mixed lineage kinase (MLK) [10].
Product References
- K-252b, c and d, potent inhibitors of protein kinase C from microbial origin: S. Nakanishi, et al.; J. Antibiot. 39, 1066 (1986)
- The structures of the novel protein kinase C inhibitors K-252a, b, c and d: T. Yasuzawa, et al.; J. Antibiot. 39, 1072 (1986)
- Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases: U.T. Ruegg & G.M. Burgess; TIPS 10, 218 (1989)
- Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds: S. Fabre, et al.; Bioorg. Med. Chem. 1, 193 (1993)
- Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C: J. Kleinschroth, et al.; Bioorg. Med. Chem. Lett. 3, 1959 (1993)
- Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp: P.A. Horton, et al.; Experientia 50, 843 (1994)
- Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase: A. Zimmermann, et al.; Antiviral Res. 48, 49 (2000)
- Kinase inhibitors: not just for kinases anymore: S.L. McGovern & B.K. Shoichet; J. Med. Chem. 46, 1478 (2003)
- Biological targets of antitumor indolocarbazoles bearing a sugar moiety: M. Prudhomme; Curr. Med. Chem. Anticancer Agents 4, 509 (2004)
- Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a: R.L. Hudkins, et al.; J. Med. Chem. 50, 433 (2007)
- Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2: R. Liu, et al.; Arch. Pharm. Res. 30, 270 (2007)
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