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AdipoGen Life Sciences
EM574
140
CHF
CHF 140.00
In stock
AG-CN2-0102-C250250 µgCHF 140.00
AG-CN2-0102-M0011 mgCHF 420.00
| Product Details | |
|---|---|
| Synonyms | Motilide; Idremcinal; 8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin |
| Product Type | Chemical |
| Properties | |
| Formula |
C39H69NO12 |
| MW | 744.0 |
| CAS | 110480-13-2 |
| Source/Host Chemicals | Semisynthetic from erythromycin A. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in methanol, ethanol, DMSO, chloroform, acetone, ethyl acetate or acetonitrile. Insoluble in water or hexane. |
| InChi Key | FPBKIOZMKHHNLL-FMUXYZBNSA-N |
| Smiles | CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C(C)C)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@]1(C)O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution, prepare aliquots and store at -20°C. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Shows strong gastrointestinal motor stimulating (GMS) activity [1, 2, 5].
- Motilin receptor agonist [3, 6].
- Stimulates smooth muscle cell contraction [3].
- Stimulates cholinergic neurons in a non-vagal pathway [4].
- Enhances gastrointestinal contractile activity and accelerates gastric emptying [7, 8].
- Shows orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, ghrelin receptor) [9].
Product References
- Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship: S. Omura, et al.; J. Antibiot. (Tokyo) 38, 1631 (1985)
- Macrolides with gastrointestinal motor stimulating activity: S. Omura, et al.; J. Med. Chem. 30, 1941 (1987)
- EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum: M. Satoh, et al.; J. Pharmacol. Exp. Ther. 271, 574 (1994)
- Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs: N. Inatomi, et al.; Jpn. J. Pharmacol. 71, 29 (1996)
- Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity: Y. Funabashi, et al.; J. Antibiot. (Tokyo) 49, 794 (1996)
- EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit: F. Sato, et al.; Eur. J. Pharmacol. 322, 63 (1997)
- Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs: T. Tanaka, et al.; J. Pharmacol. Exp. Ther. 287, 712 (1998)
- Effect of EM574 on postprandial pancreaticobiliary secretion, gastric motor activity, and emptying in conscious dogs: T. Tanaka, et al.; Dig. Dis. Sci. 44, 1100 (1999)
- EM574, a motilide, has an orexigenic activity with affinity for growth-hormone secretagogue receptor: A. Asakawa, et al.; J. Gastroenterol. Hepatol. 18, 881 (2003)